Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Berend van der Wildt, Bin Shen, Frederick T. Chin

Research output: Contribution to journalArticleAcademicpeer-review


Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.
Original languageEnglish
Pages (from-to)3124-3127
JournalChemical Communications
Issue number21
Publication statusPublished - 1 Jan 2019

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