Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Berend van der Wildt; Bin Shen; Frederick T. Chin

doi:10.1039/c8cc09661a

Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Berend van der Wildt, Bin Shen, Frederick T. Chin

Radiology and nuclear medicine

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

Original language	English
Pages (from-to)	3124-3127
Journal	Chemical Communications
Volume	55
Issue number	21
DOIs	https://doi.org/10.1039/c8cc09661a
Publication status	Published - 1 Jan 2019

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abstract = "Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.",

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AB - Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

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Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Abstract

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