Electric field causes volumetric changes in the human brain

Miklos Argyelan; Leif Oltedal; Zhi-De Deng; Benjamin Wade; Marom Bikson; Andrea Joanlanne; Sohag Sanghani; Hauke Bartsch; Marta Cano; M. Dale Anders; Udo Dannlowski; Annemiek Dols; Verena Enneking; Randall Espinoza; Ute Kessler; L. Narr Katherine; J. Oedegaard Ketil; L. Oudega Mardien; Ronny Redlich; L. Stek Max; Akihiro Takamiya; Louise Emsell; Filip Bouckaert; Pascal Sienaert; Jesus Pujol; Indira Tendolkar; Philip van Eijndhoven; Georgios Petrides; K. Malhotra Anil; Christopher Abbott

doi:10.7554/eLife.49115

Electric field causes volumetric changes in the human brain

Miklos Argyelan, Leif Oltedal, Zhi-De Deng, Benjamin Wade, Marom Bikson, Andrea Joanlanne, Sohag Sanghani, Hauke Bartsch, Marta Cano, M. Dale Anders, Udo Dannlowski, Annemiek Dols, Verena Enneking, Randall Espinoza, Ute Kessler, L. Narr Katherine, J. Oedegaard Ketil, L. Oudega Mardien, Ronny Redlich, L. Stek MaxAkihiro Takamiya, Louise Emsell, Filip Bouckaert, Pascal Sienaert, Jesus Pujol, Indira Tendolkar, Philip van Eijndhoven, Georgios Petrides, K. Malhotra Anil, Christopher Abbott

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t =3.77, df = 83, r = 0.38, p = 0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.

Original language	English
Article number	e49115
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.49115
Publication status	Published - 23 Oct 2019

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Argyelan, M., Oltedal, L., Deng, Z-D., Wade, B., Bikson, M., Joanlanne, A., Sanghani, S., Bartsch, H., Cano, M., Dale Anders, M., Dannlowski, U., Dols, A., Enneking, V., Espinoza, R., Kessler, U., Narr Katherine, L., Oedegaard Ketil, J., Oudega Mardien, L., Redlich, R., ... Abbott, C. (2019). Electric field causes volumetric changes in the human brain. eLife, 8, [e49115]. https://doi.org/10.7554/eLife.49115

@article{bff49e504bc1424abb010878bb2681d9,

title = "Electric field causes volumetric changes in the human brain",

abstract = "Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t =3.77, df = 83, r = 0.38, p = 0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.",

author = "Miklos Argyelan and Leif Oltedal and Zhi-De Deng and Benjamin Wade and Marom Bikson and Andrea Joanlanne and Sohag Sanghani and Hauke Bartsch and Marta Cano and {Dale Anders}, M. and Udo Dannlowski and Annemiek Dols and Verena Enneking and Randall Espinoza and Ute Kessler and {Narr Katherine}, L. and {Oedegaard Ketil}, J. and {Oudega Mardien}, L. and Ronny Redlich and {Stek Max}, L. and Akihiro Takamiya and Louise Emsell and Filip Bouckaert and Pascal Sienaert and Jesus Pujol and Indira Tendolkar and {van Eijndhoven}, Philip and Georgios Petrides and {Malhotra Anil}, K. and Christopher Abbott",

year = "2019",

month = oct,

day = "23",

doi = "10.7554/eLife.49115",

language = "English",

volume = "8",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Limited",

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Argyelan, M, Oltedal, L, Deng, Z-D, Wade, B, Bikson, M, Joanlanne, A, Sanghani, S, Bartsch, H, Cano, M, Dale Anders, M, Dannlowski, U, Dols, A, Enneking, V, Espinoza, R, Kessler, U, Narr Katherine, L, Oedegaard Ketil, J, Oudega Mardien, L, Redlich, R, Stek Max, L, Takamiya, A, Emsell, L, Bouckaert, F, Sienaert, P, Pujol, J, Tendolkar, I, van Eijndhoven, P, Petrides, G, Malhotra Anil, K & Abbott, C 2019, 'Electric field causes volumetric changes in the human brain', eLife, vol. 8, e49115. https://doi.org/10.7554/eLife.49115

TY - JOUR

T1 - Electric field causes volumetric changes in the human brain

AU - Argyelan, Miklos

AU - Oltedal, Leif

AU - Deng, Zhi-De

AU - Wade, Benjamin

AU - Bikson, Marom

AU - Joanlanne, Andrea

AU - Sanghani, Sohag

AU - Bartsch, Hauke

AU - Cano, Marta

AU - Dale Anders, M.

AU - Dannlowski, Udo

AU - Dols, Annemiek

AU - Enneking, Verena

AU - Espinoza, Randall

AU - Kessler, Ute

AU - Narr Katherine, L.

AU - Oedegaard Ketil, J.

AU - Oudega Mardien, L.

AU - Redlich, Ronny

AU - Stek Max, L.

AU - Takamiya, Akihiro

AU - Emsell, Louise

AU - Bouckaert, Filip

AU - Sienaert, Pascal

AU - Pujol, Jesus

AU - Tendolkar, Indira

AU - van Eijndhoven, Philip

AU - Petrides, Georgios

AU - Malhotra Anil, K.

AU - Abbott, Christopher

PY - 2019/10/23

Y1 - 2019/10/23

N2 - Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t =3.77, df = 83, r = 0.38, p = 0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.

AB - Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t =3.77, df = 83, r = 0.38, p = 0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85074525803&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31644424

U2 - 10.7554/eLife.49115

DO - 10.7554/eLife.49115

M3 - Article

C2 - 31644424

SN - 2050-084X

VL - 8

JO - eLife

JF - eLife

M1 - e49115

ER -

Electric field causes volumetric changes in the human brain

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