Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction

M L Tjoa, J M G van Vugt, A T J J Go, M A Blankenstein, C B M Oudejans, I J van Wijk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

C-reactive protein (CRP) is a marker of tissue damage and inflammation. Maternal levels of CRP are elevated in overt preeclampsia, but there is still debate about its use as a predictive marker for preeclampsia during the first and second trimesters of pregnancy. In this study, we measured CRP levels during the first trimester of pregnancy in women who later developed preeclampsia or gave birth to a growth-restricted baby. In total, 107 women from a low-risk population participated in the study, six women developed preeclampsia and nine gave birth to a growth-restricted baby. Although there is a large overlap in measured CRP levels between the three groups, mean CRP levels were significantly elevated in women who later developed preeclampsia (P=0.031) or delivered a growth-restricted baby (P=0.041) when compared with women from the control group, matched for maternal and gestational age, parity, and gravidity. This study shows that in a low-risk population, CRP levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalJournal of Reproductive Immunology
Volume59
Issue number1
Publication statusPublished - Jun 2003

Cite this

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title = "Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction",
abstract = "C-reactive protein (CRP) is a marker of tissue damage and inflammation. Maternal levels of CRP are elevated in overt preeclampsia, but there is still debate about its use as a predictive marker for preeclampsia during the first and second trimesters of pregnancy. In this study, we measured CRP levels during the first trimester of pregnancy in women who later developed preeclampsia or gave birth to a growth-restricted baby. In total, 107 women from a low-risk population participated in the study, six women developed preeclampsia and nine gave birth to a growth-restricted baby. Although there is a large overlap in measured CRP levels between the three groups, mean CRP levels were significantly elevated in women who later developed preeclampsia (P=0.031) or delivered a growth-restricted baby (P=0.041) when compared with women from the control group, matched for maternal and gestational age, parity, and gravidity. This study shows that in a low-risk population, CRP levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby.",
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author = "Tjoa, {M L} and {van Vugt}, {J M G} and Go, {A T J J} and Blankenstein, {M A} and Oudejans, {C B M} and {van Wijk}, {I J}",
year = "2003",
month = "6",
language = "English",
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pages = "29--37",
journal = "Journal of Reproductive Immunology",
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Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction. / Tjoa, M L; van Vugt, J M G; Go, A T J J; Blankenstein, M A; Oudejans, C B M; van Wijk, I J.

In: Journal of Reproductive Immunology, Vol. 59, No. 1, 06.2003, p. 29-37.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction

AU - Tjoa, M L

AU - van Vugt, J M G

AU - Go, A T J J

AU - Blankenstein, M A

AU - Oudejans, C B M

AU - van Wijk, I J

PY - 2003/6

Y1 - 2003/6

N2 - C-reactive protein (CRP) is a marker of tissue damage and inflammation. Maternal levels of CRP are elevated in overt preeclampsia, but there is still debate about its use as a predictive marker for preeclampsia during the first and second trimesters of pregnancy. In this study, we measured CRP levels during the first trimester of pregnancy in women who later developed preeclampsia or gave birth to a growth-restricted baby. In total, 107 women from a low-risk population participated in the study, six women developed preeclampsia and nine gave birth to a growth-restricted baby. Although there is a large overlap in measured CRP levels between the three groups, mean CRP levels were significantly elevated in women who later developed preeclampsia (P=0.031) or delivered a growth-restricted baby (P=0.041) when compared with women from the control group, matched for maternal and gestational age, parity, and gravidity. This study shows that in a low-risk population, CRP levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby.

AB - C-reactive protein (CRP) is a marker of tissue damage and inflammation. Maternal levels of CRP are elevated in overt preeclampsia, but there is still debate about its use as a predictive marker for preeclampsia during the first and second trimesters of pregnancy. In this study, we measured CRP levels during the first trimester of pregnancy in women who later developed preeclampsia or gave birth to a growth-restricted baby. In total, 107 women from a low-risk population participated in the study, six women developed preeclampsia and nine gave birth to a growth-restricted baby. Although there is a large overlap in measured CRP levels between the three groups, mean CRP levels were significantly elevated in women who later developed preeclampsia (P=0.031) or delivered a growth-restricted baby (P=0.041) when compared with women from the control group, matched for maternal and gestational age, parity, and gravidity. This study shows that in a low-risk population, CRP levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby.

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KW - Blood Pressure

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KW - Case-Control Studies

KW - Female

KW - Fetal Growth Retardation/blood

KW - Humans

KW - Infant, Newborn

KW - Organ Size

KW - Placenta/blood supply

KW - Pre-Eclampsia/blood

KW - Pregnancy

KW - Pregnancy Complications, Cardiovascular/blood

KW - Pregnancy Trimester, First/blood

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JO - Journal of Reproductive Immunology

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