Elevated regional cerebral blood flow in adults with 22q11.2 deletion syndrome

Maurice Pasternak, Zahra Shirzadi, Henk J. M. M. Mutsaerts, Erik Boot, Nancy J. Butcher, Bradley J. MacIntosh, Tracy Heung, Anne S. Bassett, Mario Masellis*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objectives: Recurrent chromosome 22q11.2 deletions cause 22q11 deletion syndrome (22q11DS), a multisystem disorder associated with high rates of schizophrenia. Neuroanatomical changes on brain MRI have been reported in relation to 22q11DS. However, to date no 22q11DS neuroimaging studies have examined cerebral blood flow (CBF). This exploratory case-control study seeks to identify differences in regional cerebral blood flow between 22q11DS subjects and controls, and their association with psychotic symptoms. Methods: This study of 23 adults used arterial spin labelling MRI to investigate voxel-wise CBF in 22q11DS individuals compared with age- and sex-matched healthy controls. Results: Four significant clusters, involving the right and left putamen, right fusiform gyrus and left middle temporal gyrus, delineated significantly elevated CBF in individuals with 22q11DS compared to controls. Post-hoc analysis determined that this elevation in CBF trended with psychotic symptom diagnosis within the 22q11DS group. Conclusions: These findings suggest possible relevance to schizophrenia risk and support further functional neuroimaging studies of 22q11DS with larger sample sizes to improve our understanding of the underlying pathophysiology.
Original languageEnglish
JournalWorld Journal of Biological Psychiatry
Early online date2022
Publication statusE-pub ahead of print - 2022

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