Emerging Biologics in Severe Asthma

Ian D. Pavord*, Bart Hilvering, Rahul Shrimanker

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


Asthma is a heterogeneous disease that can be classified into different clinical endotypes, depending on the type of airway inflammation, clinical severity, and response to treatment. This article focuses on the eosinophilic endotype of asthma, which is defined by the central role that eosinophils play in the pathophysiology of the condition. It is characterized by persistently elevated sputum and/or blood eosinophils and by a significant response to treatments that suppress eosinophilia. Eosinophil activity in the airway may be more important than their numbers and this needs to be investigated. Transcriplomic or Metabolomic signatures may also be useful to identify this endotype.

Original languageEnglish
Pages (from-to)609-623
Number of pages15
JournalImmunology and Allergy Clinics of North America
Issue number3
Publication statusPublished - 1 Aug 2016

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