Emotional processing and disgust sensitivity in OCD patients with and without contamination-type obsessive-compulsive symptoms – An fMRI study.

Judith Rickelt, Stella J. de Wit, Ysbrand D. van der Werf, Koen R.J. Schruers, Machteld Marcelis, Froukje E. de Vries, Odile A. van den Heuvel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Disgust is described as a relevant emotion in OCD, particularly in contamination-type OCD, and may be involved in emotional processing in this OCD-subtype. The present study aimed to investigate the neural correlates of distress processing in contamination-type compared to non-contamination-type OCD, and the relation to disgust sensitivity. Methods: Forty-three OCD patients (n = 19 contamination-type OCD) were exposed to OCD-related, fear-related and neutral pictures. Subjective distress per stimulus was assessed by a visual analogue scale (VAS) and disgust sensitivity by the DS-R. BOLD brain activation was compared between stimuli that provoked high versus low distress at individual level. Results: In contamination- and non-contamination-type OCD, the dorsomedial prefrontal cortex, operculum, visual association cortex and caudate nucleus were activated during high versus low distress. Only in contamination-type OCD, disgust sensitivity correlated positively with the VAS scores and was associated with neural activation in the dorsomedial and visual association cortex, but not with the operculum. Conclusions: Brain activation during distress processing in OCD is similar across the OCD subtypes and related to effortful emotion regulation, processing of aversive internal states and attention. In contamination-type OCD, the distress response is related to disgust sensitivity, which correlates with brain regions associated with attention and emotion regulation.

Original languageEnglish
Article number100443
JournalJournal of Obsessive-Compulsive and Related Disorders
Volume22
DOIs
Publication statusPublished - 1 Jul 2019

Cite this

@article{ac10e60ec28748f8bbd73a3ca1186973,
title = "Emotional processing and disgust sensitivity in OCD patients with and without contamination-type obsessive-compulsive symptoms – An fMRI study.",
abstract = "Objective: Disgust is described as a relevant emotion in OCD, particularly in contamination-type OCD, and may be involved in emotional processing in this OCD-subtype. The present study aimed to investigate the neural correlates of distress processing in contamination-type compared to non-contamination-type OCD, and the relation to disgust sensitivity. Methods: Forty-three OCD patients (n = 19 contamination-type OCD) were exposed to OCD-related, fear-related and neutral pictures. Subjective distress per stimulus was assessed by a visual analogue scale (VAS) and disgust sensitivity by the DS-R. BOLD brain activation was compared between stimuli that provoked high versus low distress at individual level. Results: In contamination- and non-contamination-type OCD, the dorsomedial prefrontal cortex, operculum, visual association cortex and caudate nucleus were activated during high versus low distress. Only in contamination-type OCD, disgust sensitivity correlated positively with the VAS scores and was associated with neural activation in the dorsomedial and visual association cortex, but not with the operculum. Conclusions: Brain activation during distress processing in OCD is similar across the OCD subtypes and related to effortful emotion regulation, processing of aversive internal states and attention. In contamination-type OCD, the distress response is related to disgust sensitivity, which correlates with brain regions associated with attention and emotion regulation.",
author = "Judith Rickelt and {de Wit}, {Stella J.} and {van der Werf}, {Ysbrand D.} and Schruers, {Koen R.J.} and Machteld Marcelis and {de Vries}, {Froukje E.} and {van den Heuvel}, {Odile A.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.jocrd.2019.100443",
language = "English",
volume = "22",
journal = "Journal of Obsessive-Compulsive and Related Disorders",
issn = "2211-3649",
publisher = "Elsevier Science & Technology",

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T1 - Emotional processing and disgust sensitivity in OCD patients with and without contamination-type obsessive-compulsive symptoms – An fMRI study.

AU - Rickelt, Judith

AU - de Wit, Stella J.

AU - van der Werf, Ysbrand D.

AU - Schruers, Koen R.J.

AU - Marcelis, Machteld

AU - de Vries, Froukje E.

AU - van den Heuvel, Odile A.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective: Disgust is described as a relevant emotion in OCD, particularly in contamination-type OCD, and may be involved in emotional processing in this OCD-subtype. The present study aimed to investigate the neural correlates of distress processing in contamination-type compared to non-contamination-type OCD, and the relation to disgust sensitivity. Methods: Forty-three OCD patients (n = 19 contamination-type OCD) were exposed to OCD-related, fear-related and neutral pictures. Subjective distress per stimulus was assessed by a visual analogue scale (VAS) and disgust sensitivity by the DS-R. BOLD brain activation was compared between stimuli that provoked high versus low distress at individual level. Results: In contamination- and non-contamination-type OCD, the dorsomedial prefrontal cortex, operculum, visual association cortex and caudate nucleus were activated during high versus low distress. Only in contamination-type OCD, disgust sensitivity correlated positively with the VAS scores and was associated with neural activation in the dorsomedial and visual association cortex, but not with the operculum. Conclusions: Brain activation during distress processing in OCD is similar across the OCD subtypes and related to effortful emotion regulation, processing of aversive internal states and attention. In contamination-type OCD, the distress response is related to disgust sensitivity, which correlates with brain regions associated with attention and emotion regulation.

AB - Objective: Disgust is described as a relevant emotion in OCD, particularly in contamination-type OCD, and may be involved in emotional processing in this OCD-subtype. The present study aimed to investigate the neural correlates of distress processing in contamination-type compared to non-contamination-type OCD, and the relation to disgust sensitivity. Methods: Forty-three OCD patients (n = 19 contamination-type OCD) were exposed to OCD-related, fear-related and neutral pictures. Subjective distress per stimulus was assessed by a visual analogue scale (VAS) and disgust sensitivity by the DS-R. BOLD brain activation was compared between stimuli that provoked high versus low distress at individual level. Results: In contamination- and non-contamination-type OCD, the dorsomedial prefrontal cortex, operculum, visual association cortex and caudate nucleus were activated during high versus low distress. Only in contamination-type OCD, disgust sensitivity correlated positively with the VAS scores and was associated with neural activation in the dorsomedial and visual association cortex, but not with the operculum. Conclusions: Brain activation during distress processing in OCD is similar across the OCD subtypes and related to effortful emotion regulation, processing of aversive internal states and attention. In contamination-type OCD, the distress response is related to disgust sensitivity, which correlates with brain regions associated with attention and emotion regulation.

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