Endogenous Sex Hormones and Cardiovascular Disease in Men

Majon Muller, Yvonne T. Van Der Schouw, Jos H.H. Thijssen, Diederick E. Grobbee

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Unlike women, men do not experience an abrupt reduction in endogenous sex hormone production. It has, however, become clear that an age-associated decrease in the levels of (bioactive) sex hormones does occur. Whether endogenous sex hormones have an impact on cardiovascular disease has for many years remained largely unknown, but during the last decade more attention has been drawn to the importance of testosterone, estrogens, and adrenal androgens in etiology, prevention, and treatment of male cardiovascular disease. The purpose of this article is to summarize the evidence currently available on the association between endogenous sex hormones and cardiovascular disease in males. Published studies dealing with the relationship between circulating levels of sex hormones and cardiovascular disease in males were reviewed. The studies reviewed in this article suggest that circulating endogenous sex hormones and estrogens have a neutral or beneficial effect on cardiovascular disease in men.

Original languageEnglish
Pages (from-to)5076-5086
Number of pages11
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number11
DOIs
Publication statusPublished - 1 Nov 2003

Cite this

Muller, Majon ; Van Der Schouw, Yvonne T. ; Thijssen, Jos H.H. ; Grobbee, Diederick E. / Endogenous Sex Hormones and Cardiovascular Disease in Men. In: Journal of Clinical Endocrinology and Metabolism. 2003 ; Vol. 88, No. 11. pp. 5076-5086.
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Endogenous Sex Hormones and Cardiovascular Disease in Men. / Muller, Majon; Van Der Schouw, Yvonne T.; Thijssen, Jos H.H.; Grobbee, Diederick E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 11, 01.11.2003, p. 5076-5086.

Research output: Contribution to journalReview articleAcademicpeer-review

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