Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: A randomized controlled trial (NTR 5342)

N. E. van Hoogenhuijze, H. L. Torrance, F. Mol, J. S.E. Laven, E. Scheenjes, M. A.F. Traas, C. Janssen, B. Cohlen, G. Teklenburg, J. P. de Bruin, R. van Oppenraaij, J. W.M. Maas, E. Moll, K. Fleischer, M. H. van Hooff, C. de Koning, A. Cantineau, C. B. Lambalk, M. Verberg, M. Nijs & 21 others A. P. Manger, M. van Rumste, L. F. van der Voet, A. Preys-Bosman, J. Visser, E. Brinkhuis, J. E. den Hartog, A. Sluijmer, F. W. Jansen, W. Hermes, M. L. Bandell, M. J. Pelinck, J. van Disseldorp, M. van Wely, J. Smeenk, Q. D. Pieterse, J. C. Boxmeer, E. R. Groenewoud, M. J.C. Eijkemans, J. C. Kasius, F. J.M. Broekmans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2nd fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2nd IVF/ICSI cycle and over 12months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. Discussion: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. Trial registration: NTR 5342 , registered July 31st, 2015. Protocol version: Version 4.10, January 4th, 2017.

Original languageEnglish
Article number47
JournalBMC Women's Health
Volume17
Issue number1
DOIs
Publication statusPublished - 21 Jul 2017

Cite this

van Hoogenhuijze, N. E. ; Torrance, H. L. ; Mol, F. ; Laven, J. S.E. ; Scheenjes, E. ; Traas, M. A.F. ; Janssen, C. ; Cohlen, B. ; Teklenburg, G. ; de Bruin, J. P. ; van Oppenraaij, R. ; Maas, J. W.M. ; Moll, E. ; Fleischer, K. ; van Hooff, M. H. ; de Koning, C. ; Cantineau, A. ; Lambalk, C. B. ; Verberg, M. ; Nijs, M. ; Manger, A. P. ; van Rumste, M. ; van der Voet, L. F. ; Preys-Bosman, A. ; Visser, J. ; Brinkhuis, E. ; den Hartog, J. E. ; Sluijmer, A. ; Jansen, F. W. ; Hermes, W. ; Bandell, M. L. ; Pelinck, M. J. ; van Disseldorp, J. ; van Wely, M. ; Smeenk, J. ; Pieterse, Q. D. ; Boxmeer, J. C. ; Groenewoud, E. R. ; Eijkemans, M. J.C. ; Kasius, J. C. ; Broekmans, F. J.M. / Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study : A randomized controlled trial (NTR 5342). In: BMC Women's Health. 2017 ; Vol. 17, No. 1.
@article{3cf21633ce2c483f82ffc9cb736062c6,
title = "Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: A randomized controlled trial (NTR 5342)",
abstract = "Background: Success rates of assisted reproductive techniques (ART) are approximately 30{\%}, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2nd fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2nd IVF/ICSI cycle and over 12months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. Discussion: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. Trial registration: NTR 5342 , registered July 31st, 2015. Protocol version: Version 4.10, January 4th, 2017.",
keywords = "Endometrial injury, Endometrial scratch, Endometrial scratching, ICSI, Implantation failure, In vitro fertilization, Intracytoplasmic sperm injection, IVF",
author = "{van Hoogenhuijze}, {N. E.} and Torrance, {H. L.} and F. Mol and Laven, {J. S.E.} and E. Scheenjes and Traas, {M. A.F.} and C. Janssen and B. Cohlen and G. Teklenburg and {de Bruin}, {J. P.} and {van Oppenraaij}, R. and Maas, {J. W.M.} and E. Moll and K. Fleischer and {van Hooff}, {M. H.} and {de Koning}, C. and A. Cantineau and Lambalk, {C. B.} and M. Verberg and M. Nijs and Manger, {A. P.} and {van Rumste}, M. and {van der Voet}, {L. F.} and A. Preys-Bosman and J. Visser and E. Brinkhuis and {den Hartog}, {J. E.} and A. Sluijmer and Jansen, {F. W.} and W. Hermes and Bandell, {M. L.} and Pelinck, {M. J.} and {van Disseldorp}, J. and {van Wely}, M. and J. Smeenk and Pieterse, {Q. D.} and Boxmeer, {J. C.} and Groenewoud, {E. R.} and Eijkemans, {M. J.C.} and Kasius, {J. C.} and Broekmans, {F. J.M.}",
year = "2017",
month = "7",
day = "21",
doi = "10.1186/s12905-017-0378-y",
language = "English",
volume = "17",
journal = "BMC Women's Health",
issn = "1472-6874",
publisher = "BioMed Central",
number = "1",

}

van Hoogenhuijze, NE, Torrance, HL, Mol, F, Laven, JSE, Scheenjes, E, Traas, MAF, Janssen, C, Cohlen, B, Teklenburg, G, de Bruin, JP, van Oppenraaij, R, Maas, JWM, Moll, E, Fleischer, K, van Hooff, MH, de Koning, C, Cantineau, A, Lambalk, CB, Verberg, M, Nijs, M, Manger, AP, van Rumste, M, van der Voet, LF, Preys-Bosman, A, Visser, J, Brinkhuis, E, den Hartog, JE, Sluijmer, A, Jansen, FW, Hermes, W, Bandell, ML, Pelinck, MJ, van Disseldorp, J, van Wely, M, Smeenk, J, Pieterse, QD, Boxmeer, JC, Groenewoud, ER, Eijkemans, MJC, Kasius, JC & Broekmans, FJM 2017, 'Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: A randomized controlled trial (NTR 5342)' BMC Women's Health, vol. 17, no. 1, 47. https://doi.org/10.1186/s12905-017-0378-y

Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study : A randomized controlled trial (NTR 5342). / van Hoogenhuijze, N. E.; Torrance, H. L.; Mol, F.; Laven, J. S.E.; Scheenjes, E.; Traas, M. A.F.; Janssen, C.; Cohlen, B.; Teklenburg, G.; de Bruin, J. P.; van Oppenraaij, R.; Maas, J. W.M.; Moll, E.; Fleischer, K.; van Hooff, M. H.; de Koning, C.; Cantineau, A.; Lambalk, C. B.; Verberg, M.; Nijs, M.; Manger, A. P.; van Rumste, M.; van der Voet, L. F.; Preys-Bosman, A.; Visser, J.; Brinkhuis, E.; den Hartog, J. E.; Sluijmer, A.; Jansen, F. W.; Hermes, W.; Bandell, M. L.; Pelinck, M. J.; van Disseldorp, J.; van Wely, M.; Smeenk, J.; Pieterse, Q. D.; Boxmeer, J. C.; Groenewoud, E. R.; Eijkemans, M. J.C.; Kasius, J. C.; Broekmans, F. J.M.

In: BMC Women's Health, Vol. 17, No. 1, 47, 21.07.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study

T2 - A randomized controlled trial (NTR 5342)

AU - van Hoogenhuijze, N. E.

AU - Torrance, H. L.

AU - Mol, F.

AU - Laven, J. S.E.

AU - Scheenjes, E.

AU - Traas, M. A.F.

AU - Janssen, C.

AU - Cohlen, B.

AU - Teklenburg, G.

AU - de Bruin, J. P.

AU - van Oppenraaij, R.

AU - Maas, J. W.M.

AU - Moll, E.

AU - Fleischer, K.

AU - van Hooff, M. H.

AU - de Koning, C.

AU - Cantineau, A.

AU - Lambalk, C. B.

AU - Verberg, M.

AU - Nijs, M.

AU - Manger, A. P.

AU - van Rumste, M.

AU - van der Voet, L. F.

AU - Preys-Bosman, A.

AU - Visser, J.

AU - Brinkhuis, E.

AU - den Hartog, J. E.

AU - Sluijmer, A.

AU - Jansen, F. W.

AU - Hermes, W.

AU - Bandell, M. L.

AU - Pelinck, M. J.

AU - van Disseldorp, J.

AU - van Wely, M.

AU - Smeenk, J.

AU - Pieterse, Q. D.

AU - Boxmeer, J. C.

AU - Groenewoud, E. R.

AU - Eijkemans, M. J.C.

AU - Kasius, J. C.

AU - Broekmans, F. J.M.

PY - 2017/7/21

Y1 - 2017/7/21

N2 - Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2nd fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2nd IVF/ICSI cycle and over 12months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. Discussion: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. Trial registration: NTR 5342 , registered July 31st, 2015. Protocol version: Version 4.10, January 4th, 2017.

AB - Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2nd fresh IVF/ICSI cycle. Secondary endpoints are costs, cumulative live birth rate (after the full 2nd IVF/ICSI cycle and over 12months of follow-up); clinical and ongoing pregnancy rate; multiple pregnancy rate; miscarriage rate and endometrial tissue parameters associated with implantation failure. Discussion: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle. Trial registration: NTR 5342 , registered July 31st, 2015. Protocol version: Version 4.10, January 4th, 2017.

KW - Endometrial injury

KW - Endometrial scratch

KW - Endometrial scratching

KW - ICSI

KW - Implantation failure

KW - In vitro fertilization

KW - Intracytoplasmic sperm injection

KW - IVF

UR - http://www.scopus.com/inward/record.url?scp=85025073581&partnerID=8YFLogxK

U2 - 10.1186/s12905-017-0378-y

DO - 10.1186/s12905-017-0378-y

M3 - Article

VL - 17

JO - BMC Women's Health

JF - BMC Women's Health

SN - 1472-6874

IS - 1

M1 - 47

ER -