Endoplasmic Reticulum Stress in Neurodegeneration

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response called the unfolded protein response (UPR) that protects the cell against the toxic buildup of misfolded proteins. Neurodegenerative disorders like Alzheimer’s disease, Parkinson’s disease, prion disease, Huntington’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis are characterized by the accumulation and aggregation of misfolded proteins. In this chapter we will discuss the different levels of protein quality control systems in the endoplasmic reticulum. The role of these systems and especially the UPR will be reviewed in view of current data about the expression and role of the UPR markers in the pathology of neurodegenerative disorders.
Original languageEnglish
Title of host publicationProtein Folding and Misfolding: Neurodegenerative Diseases
EditorsJudit Ovádi, Ferenc Orosz
Place of PublicationDordrecht
PublisherSpringer Netherlands
Pages111-132
Number of pages22
ISBN (Print)978-1-4020-9434-7
DOIs
Publication statusPublished - 2009

Cite this

Hoozemans, J. J. M., & Scheper, W. (2009). Endoplasmic Reticulum Stress in Neurodegeneration. In J. Ovádi, & F. Orosz (Eds.), Protein Folding and Misfolding: Neurodegenerative Diseases (pp. 111-132). Dordrecht: Springer Netherlands. https://doi.org/10.1007/978-1-4020-9434-7_5
Hoozemans, Jeroen J.M. ; Scheper, Wiep. / Endoplasmic Reticulum Stress in Neurodegeneration. Protein Folding and Misfolding: Neurodegenerative Diseases. editor / Judit Ovádi ; Ferenc Orosz. Dordrecht : Springer Netherlands, 2009. pp. 111-132
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Hoozemans, JJM & Scheper, W 2009, Endoplasmic Reticulum Stress in Neurodegeneration. in J Ovádi & F Orosz (eds), Protein Folding and Misfolding: Neurodegenerative Diseases. Springer Netherlands, Dordrecht, pp. 111-132. https://doi.org/10.1007/978-1-4020-9434-7_5

Endoplasmic Reticulum Stress in Neurodegeneration. / Hoozemans, Jeroen J.M.; Scheper, Wiep.

Protein Folding and Misfolding: Neurodegenerative Diseases. ed. / Judit Ovádi; Ferenc Orosz. Dordrecht : Springer Netherlands, 2009. p. 111-132.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Hoozemans JJM, Scheper W. Endoplasmic Reticulum Stress in Neurodegeneration. In Ovádi J, Orosz F, editors, Protein Folding and Misfolding: Neurodegenerative Diseases. Dordrecht: Springer Netherlands. 2009. p. 111-132 https://doi.org/10.1007/978-1-4020-9434-7_5