Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

Diewertje I. Bink; Jessica Pauli; Lars Maegdefessel; Reinier A. Boon

doi:10.1016/j.atherosclerosis.2023.03.019

Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

Diewertje I. Bink, Jessica Pauli, Lars Maegdefessel, Reinier A. Boon^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.

Original language	English
Journal	Atherosclerosis
Early online date	2023
DOIs	https://doi.org/10.1016/j.atherosclerosis.2023.03.019
Publication status	E-pub ahead of print - 2023

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10.1016/j.atherosclerosis.2023.03.019

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title = "Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing",

abstract = "Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.",

keywords = "Ageing, Endothelial cells, Non-coding RNA, lncRNA, microRNA",

author = "Bink, {Diewertje I.} and Jessica Pauli and Lars Maegdefessel and Boon, {Reinier A.}",

note = "Funding Information: This work was funded by the collaborative research center TRR267 of the German Research Council (DFG) (Project B04 to LM and RAB) and the European Research Council (ERC Consolidator “NICCA” to RAB)). Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

doi = "10.1016/j.atherosclerosis.2023.03.019",

language = "English",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

AU - Bink, Diewertje I.

AU - Pauli, Jessica

AU - Maegdefessel, Lars

AU - Boon, Reinier A.

N1 - Funding Information: This work was funded by the collaborative research center TRR267 of the German Research Council (DFG) (Project B04 to LM and RAB) and the European Research Council (ERC Consolidator “NICCA” to RAB)). Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.

AB - Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.

KW - Ageing

KW - Endothelial cells

KW - Non-coding RNA

KW - lncRNA

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=85152248715&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2023.03.019

DO - 10.1016/j.atherosclerosis.2023.03.019

M3 - Review article

C2 - 37059656

SN - 0021-9150

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

Abstract

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