Endothelial permeability, LDL deposition, and cardiovascular risk factors-A review

Santa Mundi, Marika Massaro, Egeria Scoditti, Maria Annunziata Carluccio, Victor W. M. van Hinsbergh, Marial Luisa Iruela-Arispe, Raffaele de Caterina

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Early atherosclerosis features functional and structural changes in the endothelial barrier function that affect the traffic of molecules and solutes between the vessel lumen and the vascular wall. Such changes are mechanistically related to the development of atherosclerosis. Proatherogenic stimuli and cardiovascular risk factors, such as dyslipidaemias, diabetes, obesity, and smoking, all increase endothelial permeability sharing a common signalling denominator: An imbalance in the production/disposal of reactive oxygen species (ROS), broadly termed oxidative stress. Mostly as a consequence of the activation of enzymatic systems leading to ROS overproduction, proatherogenic factors lead to a pro-inflammatory status that translates in changes in gene expression and functional rearrangements, including changes in the transendothelial transport of molecules, leading to the deposition of low-density lipoproteins (LDL) and the subsequent infiltration of circulating leucocytes in the intima. In this review, we focus on such early changes in atherogenesis and on the concept that proatherogenic stimuli and risk factors for cardiovascular disease, by altering the endothelial barrier properties, co-ordinately trigger the accumulation of LDL in the intima and ultimately plaque formation.
Original languageEnglish
Pages (from-to)35-52
JournalCardiovascular Research
Issue number1
Publication statusPublished - 2018
Externally publishedYes

Cite this

Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., van Hinsbergh, V. W. M., Iruela-Arispe, M. L., & de Caterina, R. (2018). Endothelial permeability, LDL deposition, and cardiovascular risk factors-A review. Cardiovascular Research, 114(1), 35-52. https://doi.org/10.1093/cvr/cvx226