Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19

Anno Saris, Tom D Y Reijnders, Martine Reijm, Jolien C Hollander, Kim de Buck, Alex R Schuurman, JanWillem Duitman, Leo Heunks, Jurjan Aman, Harm Jan Bogaard, Esther J Nossent, Tom van der Poll, Hetty J Bontkes, Amsterdam UMC COVID study group

Research output: Contribution to journalLetterAcademicpeer-review

Abstract

Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. ​.

Original languageEnglish
Pages (from-to)1535-1538
Number of pages4
JournalEuropean Journal of Immunology
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 2021

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