Error processing and inhibitory control in Obsessive-Compulsive Disorder: A meta-analysis using statistical parametric maps

Luke J Norman, Stephan F Taylor, Yanni Liu, Joaquim Radua, Yann Chye, Stella J De Wit, Chaim Huyser, F Isik Karahanoglu, Tracy Luks, Dara Manoach, Carol Mathews, Katya Rubia, Chao Suo, Odile A van den Heuvel, Murat Yücel, Kate Fitzgerald

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods: A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results: Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p =.03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p =.02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p <.001). Conclusions: A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

Original languageEnglish
Pages (from-to)713-725
Number of pages13
JournalBiological Psychiatry
Volume85
Issue number9
DOIs
Publication statusPublished - 1 May 2019

Cite this

Norman, Luke J ; Taylor, Stephan F ; Liu, Yanni ; Radua, Joaquim ; Chye, Yann ; De Wit, Stella J ; Huyser, Chaim ; Karahanoglu, F Isik ; Luks, Tracy ; Manoach, Dara ; Mathews, Carol ; Rubia, Katya ; Suo, Chao ; van den Heuvel, Odile A ; Yücel, Murat ; Fitzgerald, Kate. / Error processing and inhibitory control in Obsessive-Compulsive Disorder : A meta-analysis using statistical parametric maps. In: Biological Psychiatry. 2019 ; Vol. 85, No. 9. pp. 713-725.
@article{b841d18fe86c4647937eea6017fd90a1,
title = "Error processing and inhibitory control in Obsessive-Compulsive Disorder: A meta-analysis using statistical parametric maps",
abstract = "Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods: A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results: Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p =.03, 95{\%} confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p =.02, 95{\%} confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p <.001). Conclusions: A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.",
keywords = "Error processing, Inhibitory control, Meta-analysis, OCD, Performance monitoring, fMRI",
author = "Norman, {Luke J} and Taylor, {Stephan F} and Yanni Liu and Joaquim Radua and Yann Chye and {De Wit}, {Stella J} and Chaim Huyser and Karahanoglu, {F Isik} and Tracy Luks and Dara Manoach and Carol Mathews and Katya Rubia and Chao Suo and {van den Heuvel}, {Odile A} and Murat Y{\"u}cel and Kate Fitzgerald",
note = "Copyright {\circledC} 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.biopsych.2018.11.010",
language = "English",
volume = "85",
pages = "713--725",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",

}

Norman, LJ, Taylor, SF, Liu, Y, Radua, J, Chye, Y, De Wit, SJ, Huyser, C, Karahanoglu, FI, Luks, T, Manoach, D, Mathews, C, Rubia, K, Suo, C, van den Heuvel, OA, Yücel, M & Fitzgerald, K 2019, 'Error processing and inhibitory control in Obsessive-Compulsive Disorder: A meta-analysis using statistical parametric maps' Biological Psychiatry, vol. 85, no. 9, pp. 713-725. https://doi.org/10.1016/j.biopsych.2018.11.010

Error processing and inhibitory control in Obsessive-Compulsive Disorder : A meta-analysis using statistical parametric maps. / Norman, Luke J; Taylor, Stephan F; Liu, Yanni; Radua, Joaquim; Chye, Yann; De Wit, Stella J; Huyser, Chaim; Karahanoglu, F Isik; Luks, Tracy; Manoach, Dara; Mathews, Carol; Rubia, Katya; Suo, Chao; van den Heuvel, Odile A; Yücel, Murat; Fitzgerald, Kate.

In: Biological Psychiatry, Vol. 85, No. 9, 01.05.2019, p. 713-725.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Error processing and inhibitory control in Obsessive-Compulsive Disorder

T2 - A meta-analysis using statistical parametric maps

AU - Norman, Luke J

AU - Taylor, Stephan F

AU - Liu, Yanni

AU - Radua, Joaquim

AU - Chye, Yann

AU - De Wit, Stella J

AU - Huyser, Chaim

AU - Karahanoglu, F Isik

AU - Luks, Tracy

AU - Manoach, Dara

AU - Mathews, Carol

AU - Rubia, Katya

AU - Suo, Chao

AU - van den Heuvel, Odile A

AU - Yücel, Murat

AU - Fitzgerald, Kate

N1 - Copyright © 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods: A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results: Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p =.03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p =.02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p <.001). Conclusions: A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

AB - Background: Error processing and inhibitory control enable the adjustment of behaviors to meet task demands. Functional magnetic resonance imaging studies report brain activation abnormalities in patients with obsessive-compulsive disorder (OCD) during both processes. However, conclusions are limited by inconsistencies in the literature and small sample sizes. Therefore, the aim here was to perform a meta-analysis of the existing literature using unthresholded statistical maps from previous studies. Methods: A voxelwise seed-based d mapping meta-analysis was performed using t-maps from studies comparing patients with OCD and healthy control subjects (HCs) during error processing and inhibitory control. For the error processing analysis, 239 patients with OCD (120 male; 79 medicated) and 229 HCs (129 male) were included, while the inhibitory control analysis included 245 patients with OCD (120 male; 91 medicated) and 239 HCs (135 male). Results: Patients with OCD, relative to HCs, showed longer inhibitory control reaction time (standardized mean difference = 0.20, p =.03, 95% confidence interval = 0.016, 0.393) and more inhibitory control errors (standardized mean difference = 0.22, p =.02, 95% confidence interval = 0.039, 0.399). In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingulate cortex, supplementary motor area, and pre-supplementary motor area as well as right anterior insula/frontal operculum and anterior lateral prefrontal cortex during error processing but showed hypoactivation during inhibitory control in the rostral and ventral anterior cingulate cortices and bilateral thalamus/caudate, as well as the right anterior insula/frontal operculum, supramarginal gyrus, and medial orbitofrontal cortex (all seed-based d mapping z value >2, p <.001). Conclusions: A hyperactive error processing mechanism in conjunction with impairments in implementing inhibitory control may underlie deficits in stopping unwanted compulsive behaviors in the disorder.

KW - Error processing

KW - Inhibitory control

KW - Meta-analysis

KW - OCD

KW - Performance monitoring

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=85063535978&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2018.11.010

DO - 10.1016/j.biopsych.2018.11.010

M3 - Article

VL - 85

SP - 713

EP - 725

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -