European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders

Abdulbaqi Al-Toma, Umberto Volta, Renata Auricchio, Gemma Castillejo, David S. Sanders, Christophe Cellier, Chris J. Mulder, Knut E. A. Lundin

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.
Original languageEnglish
JournalUnited European Gastroenterology Journal
DOIs
Publication statusPublished - 2019

Cite this

Al-Toma, Abdulbaqi ; Volta, Umberto ; Auricchio, Renata ; Castillejo, Gemma ; Sanders, David S. ; Cellier, Christophe ; Mulder, Chris J. ; Lundin, Knut E. A. / European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. In: United European Gastroenterology Journal. 2019.
@article{014552bd0bcb4408b5330c6f3b72b1e6,
title = "European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders",
abstract = "This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.",
author = "Abdulbaqi Al-Toma and Umberto Volta and Renata Auricchio and Gemma Castillejo and Sanders, {David S.} and Christophe Cellier and Mulder, {Chris J.} and Lundin, {Knut E. A.}",
year = "2019",
doi = "10.1177/2050640619844125",
language = "English",
journal = "United European Gastroenterology Journal",
issn = "2050-6406",
publisher = "SAGE Publications Inc.",

}

European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. / Al-Toma, Abdulbaqi; Volta, Umberto; Auricchio, Renata; Castillejo, Gemma; Sanders, David S.; Cellier, Christophe; Mulder, Chris J.; Lundin, Knut E. A.

In: United European Gastroenterology Journal, 2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders

AU - Al-Toma, Abdulbaqi

AU - Volta, Umberto

AU - Auricchio, Renata

AU - Castillejo, Gemma

AU - Sanders, David S.

AU - Cellier, Christophe

AU - Mulder, Chris J.

AU - Lundin, Knut E. A.

PY - 2019

Y1 - 2019

N2 - This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.

AB - This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. The diagnosis of CD is based on a combination of clinical, serological and histopathological data. In a group of children the diagnosis may be made without biopsy if strict criteria are available. The treatment for CD is primarily a gluten-free diet (GFD), which requires significant patient education, motivation and follow-up. Slow-responsiveness occurs frequently, particularly in those diagnosed in adulthood. Persistent or recurring symptoms necessitate a review of the original diagnosis, exclude alternative diagnoses, confirm dietary adherence (dietary review and serology) and follow-up biopsy. In addition, evaluation to exclude complications of CD, such as refractory CD or lymphoma, should be performed. The guideline also deals with other gluten-related disorders, such as dermatitis herpetiformis, which is a cutaneous manifestation of CD characterized by granular IgA deposits in the dermal papillae. The skin lesions clear with gluten withdrawal. Also, less well-defined conditions such as non-coeliac gluten sensitivity (NCGS) and gluten-sensitive neurological manifestations, such as ataxia, have been addressed. Newer therapeutic modalities for CD are being studied in clinical trials but are not yet approved for use in practice.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064572800&origin=inward

U2 - 10.1177/2050640619844125

DO - 10.1177/2050640619844125

M3 - Review article

JO - United European Gastroenterology Journal

JF - United European Gastroenterology Journal

SN - 2050-6406

ER -