Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease

Karin Horsthuis; Manon L W Ziech; Shandra Bipat; Anje M Spijkerboer; Annette C de Bruine-Dobben; Daniel W Hommes; Jaap Stoker

doi:10.1016/j.clinimag.2010.09.003

Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease

Karin Horsthuis, Manon L W Ziech, Shandra Bipat, Anje M Spijkerboer, Annette C de Bruine-Dobben, Daniel W Hommes, Jaap Stoker

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To evaluate a magnetic resonance imaging (MRI)-based score of disease severity for perianal fistulizing Crohn's disease (CD), 16 patients with perianal fistulizing CD underwent 1.5-T MRI before and after infliximab therapy. MRI scores, Perianal Disease Activity Index (PDAI) and C-reactive protein (CRP) were calculated, and fistula drainage was assessed. These items were compared for responders and nonresponders. After therapy, PDAI values and CRP values decreased significantly in responders, but there were no significant differences in the MRI scores. In all responders, MRI findings were indicative of persisting active inflammation. In these patients, a relapse rate of 57% was seen.

Original language	English
Pages (from-to)	360-5
Number of pages	6
Journal	Clinical imaging
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.clinimag.2010.09.003
Publication status	Published - 30 Aug 2011

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10.1016/j.clinimag.2010.09.003

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@article{ac1af7408b4741c383eb1d3da31d3881,

title = "Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease",

abstract = "To evaluate a magnetic resonance imaging (MRI)-based score of disease severity for perianal fistulizing Crohn's disease (CD), 16 patients with perianal fistulizing CD underwent 1.5-T MRI before and after infliximab therapy. MRI scores, Perianal Disease Activity Index (PDAI) and C-reactive protein (CRP) were calculated, and fistula drainage was assessed. These items were compared for responders and nonresponders. After therapy, PDAI values and CRP values decreased significantly in responders, but there were no significant differences in the MRI scores. In all responders, MRI findings were indicative of persisting active inflammation. In these patients, a relapse rate of 57% was seen.",

keywords = "Adolescent, Adult, Antibodies, Monoclonal/therapeutic use, Biomarkers/analysis, C-Reactive Protein/analysis, Crohn Disease/drug therapy, Female, Gadolinium DTPA, Gastrointestinal Agents/therapeutic use, Humans, Infliximab, Magnetic Resonance Imaging/methods, Male, Middle Aged, Rectal Fistula/pathology, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome",

author = "Karin Horsthuis and Ziech, {Manon L W} and Shandra Bipat and Spijkerboer, {Anje M} and {de Bruine-Dobben}, {Annette C} and Hommes, {Daniel W} and Jaap Stoker",

year = "2011",

month = aug,

day = "30",

doi = "10.1016/j.clinimag.2010.09.003",

language = "English",

volume = "35",

pages = "360--5",

journal = "Clinical imaging",

issn = "0899-7071",

publisher = "Elsevier Inc.",

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T1 - Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease

AU - Horsthuis, Karin

AU - Ziech, Manon L W

AU - Bipat, Shandra

AU - Spijkerboer, Anje M

AU - de Bruine-Dobben, Annette C

AU - Hommes, Daniel W

AU - Stoker, Jaap

PY - 2011/8/30

Y1 - 2011/8/30

N2 - To evaluate a magnetic resonance imaging (MRI)-based score of disease severity for perianal fistulizing Crohn's disease (CD), 16 patients with perianal fistulizing CD underwent 1.5-T MRI before and after infliximab therapy. MRI scores, Perianal Disease Activity Index (PDAI) and C-reactive protein (CRP) were calculated, and fistula drainage was assessed. These items were compared for responders and nonresponders. After therapy, PDAI values and CRP values decreased significantly in responders, but there were no significant differences in the MRI scores. In all responders, MRI findings were indicative of persisting active inflammation. In these patients, a relapse rate of 57% was seen.

AB - To evaluate a magnetic resonance imaging (MRI)-based score of disease severity for perianal fistulizing Crohn's disease (CD), 16 patients with perianal fistulizing CD underwent 1.5-T MRI before and after infliximab therapy. MRI scores, Perianal Disease Activity Index (PDAI) and C-reactive protein (CRP) were calculated, and fistula drainage was assessed. These items were compared for responders and nonresponders. After therapy, PDAI values and CRP values decreased significantly in responders, but there were no significant differences in the MRI scores. In all responders, MRI findings were indicative of persisting active inflammation. In these patients, a relapse rate of 57% was seen.

KW - Adolescent

KW - Adult

KW - Antibodies, Monoclonal/therapeutic use

KW - Biomarkers/analysis

KW - C-Reactive Protein/analysis

KW - Crohn Disease/drug therapy

KW - Female

KW - Gadolinium DTPA

KW - Gastrointestinal Agents/therapeutic use

KW - Humans

KW - Infliximab

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Middle Aged

KW - Rectal Fistula/pathology

KW - Severity of Illness Index

KW - Statistics, Nonparametric

KW - Treatment Outcome

U2 - 10.1016/j.clinimag.2010.09.003

DO - 10.1016/j.clinimag.2010.09.003

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C2 - 21872125

SN - 0899-7071

VL - 35

SP - 360

EP - 365

JO - Clinical imaging

JF - Clinical imaging

IS - 5

ER -