Executive function deficits in children born preterm or at low birthweight: a meta-analysis

Carolien A. van Houdt, Jaap Oosterlaan, Aleid G. van Wassenaer-Leemhuis, Anton H. van Kaam, Cornelieke S. H. Aarnoudse-Moens

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Abstract

Aim: To investigate the magnitude of executive function deficits and their dependency on gestational age, sex, age at assessment, and year of birth for children born preterm and/or at low birthweight. Method: PubMed, PsychINFO, Web of Science, and ERIC were searched for studies reporting on executive functions in children born preterm/low birthweight and term controls born in 1990 and later, assessed at a mean age of 4 years or higher. Studies were included if five or more studies reported on the same executive function measures. Results: Thirty-five studies (3360 children born preterm/low birthweight, 2812 controls) were included. Children born preterm/low birthweight performed 0.5 standardized mean difference (SMD) lower on working memory and cognitive flexibility and 0.4 SMD lower on inhibition. SMDs for these executive functions did not significantly differ from each other. Meta-regression showed that heterogeneity in SMDs for working memory and inhibition could not be explained by study differences in gestational age, sex, age at assessment, or year of birth. Interpretation: Children born preterm/low birthweight since 1990 perform half a SMD below term-born peers on executive function, which does not seem to improve with more recent advances in medical care or with increasing age. What this paper adds: Children born preterm/low birthweight perform below term-born children on core executive functions. Lower gestational age or male sex are not risk factors for poorer executive functions. Executive function difficulties in children born preterm/low birthweight remain stable across childhood. Executive function difficulties are similar for children born recently and children born in earlier eras.
Original languageEnglish
Pages (from-to)1015-1024
JournalDevelopmental Medicine and Child Neurology
Volume61
Issue number9
DOIs
Publication statusPublished - Sep 2019

Cite this

van Houdt, C. A., Oosterlaan, J., van Wassenaer-Leemhuis, A. G., van Kaam, A. H., & Aarnoudse-Moens, C. S. H. (2019). Executive function deficits in children born preterm or at low birthweight: a meta-analysis. Developmental Medicine and Child Neurology, 61(9), 1015-1024. https://doi.org/10.1111/dmcn.14213