Executive functions and prefrontal cortex: a matter of persistence?

Gareth Ball, Paul R Stokes, Rebecca A Rhodes, Subrata K Bose, Iead Rezek, Alle-Meije Wink, Louis-David Lord, Mitul A Mehta, Paul M Grasby, Federico E Turkheimer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of executive function. A numerical estimate of signal persistence, the Hurst exponent, postulated to represent the coherent firing of cortical networks, was determined and correlated with task performance. Increasing persistence in the lateral PFC was shown to correlate with improved performance during an n-back task. Conversely, we observed a correlation between persistence and increasing commission error - indicating a failure to inhibit a prepotent response - during a Go/No-Go task. We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions.

Original languageEnglish
Pages (from-to)3
JournalFrontiers in Systems Neuroscience
Volume5
DOIs
Publication statusPublished - 2011

Cite this

Ball, G., Stokes, P. R., Rhodes, R. A., Bose, S. K., Rezek, I., Wink, A-M., ... Turkheimer, F. E. (2011). Executive functions and prefrontal cortex: a matter of persistence? Frontiers in Systems Neuroscience, 5, 3. https://doi.org/10.3389/fnsys.2011.00003
Ball, Gareth ; Stokes, Paul R ; Rhodes, Rebecca A ; Bose, Subrata K ; Rezek, Iead ; Wink, Alle-Meije ; Lord, Louis-David ; Mehta, Mitul A ; Grasby, Paul M ; Turkheimer, Federico E. / Executive functions and prefrontal cortex : a matter of persistence?. In: Frontiers in Systems Neuroscience. 2011 ; Vol. 5. pp. 3.
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title = "Executive functions and prefrontal cortex: a matter of persistence?",
abstract = "Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of executive function. A numerical estimate of signal persistence, the Hurst exponent, postulated to represent the coherent firing of cortical networks, was determined and correlated with task performance. Increasing persistence in the lateral PFC was shown to correlate with improved performance during an n-back task. Conversely, we observed a correlation between persistence and increasing commission error - indicating a failure to inhibit a prepotent response - during a Go/No-Go task. We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions.",
author = "Gareth Ball and Stokes, {Paul R} and Rhodes, {Rebecca A} and Bose, {Subrata K} and Iead Rezek and Alle-Meije Wink and Louis-David Lord and Mehta, {Mitul A} and Grasby, {Paul M} and Turkheimer, {Federico E}",
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Ball, G, Stokes, PR, Rhodes, RA, Bose, SK, Rezek, I, Wink, A-M, Lord, L-D, Mehta, MA, Grasby, PM & Turkheimer, FE 2011, 'Executive functions and prefrontal cortex: a matter of persistence?' Frontiers in Systems Neuroscience, vol. 5, pp. 3. https://doi.org/10.3389/fnsys.2011.00003

Executive functions and prefrontal cortex : a matter of persistence? / Ball, Gareth; Stokes, Paul R; Rhodes, Rebecca A; Bose, Subrata K; Rezek, Iead; Wink, Alle-Meije; Lord, Louis-David; Mehta, Mitul A; Grasby, Paul M; Turkheimer, Federico E.

In: Frontiers in Systems Neuroscience, Vol. 5, 2011, p. 3.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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T2 - a matter of persistence?

AU - Ball, Gareth

AU - Stokes, Paul R

AU - Rhodes, Rebecca A

AU - Bose, Subrata K

AU - Rezek, Iead

AU - Wink, Alle-Meije

AU - Lord, Louis-David

AU - Mehta, Mitul A

AU - Grasby, Paul M

AU - Turkheimer, Federico E

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AB - Executive function is thought to originates from the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level dependent time-series measured with functional MRI (fMRI) within the prefrontal cortex (PFC) to test the hypothesis that temporally persistent neural activity underlies performance in three tasks of executive function. A numerical estimate of signal persistence, the Hurst exponent, postulated to represent the coherent firing of cortical networks, was determined and correlated with task performance. Increasing persistence in the lateral PFC was shown to correlate with improved performance during an n-back task. Conversely, we observed a correlation between persistence and increasing commission error - indicating a failure to inhibit a prepotent response - during a Go/No-Go task. We propose that persistence within the PFC reflects dynamic network formation and these findings underline the importance of frequency analysis of fMRI time-series in the study of executive functions.

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