Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia: A systematic review and meta-analysis

Meenakshi Dauwan, Marieke J H Begemann, Sophie M. Heringa, Iris E. Sommer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. Methods: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. Results: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g =. 39, P <. 001), positive (k = 15, n = 715: Hedges' g =. 32, P <. 01), negative (k = 18, n = 854: Hedges' g =. 49, P <. 001), and general (k = 10, n = 475: Hedges' g =. 27, P <. 05) symptoms, quality of life (k = 11, n = 770: Hedges' g =. 55, P <. 001), global functioning (k = 5, n = 342: Hedges' g =. 32, P <. 01), and depressive symptoms (k = 7, n = 337: Hedges' g =. 71, P <. 001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g =. 32, P <. 05), while exercise in general or in any other form had no effect on cognition. Conclusion: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.

Original languageEnglish
Pages (from-to)588-599
Number of pages12
JournalSchizophrenia Bulletin
Volume42
Issue number3
DOIs
Publication statusPublished - 1 May 2016

Cite this

@article{1956c8dd91f742c8887393547fc6b040,
title = "Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia: A systematic review and meta-analysis",
abstract = "Background: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. Methods: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. Results: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g =. 39, P <. 001), positive (k = 15, n = 715: Hedges' g =. 32, P <. 01), negative (k = 18, n = 854: Hedges' g =. 49, P <. 001), and general (k = 10, n = 475: Hedges' g =. 27, P <. 05) symptoms, quality of life (k = 11, n = 770: Hedges' g =. 55, P <. 001), global functioning (k = 5, n = 342: Hedges' g =. 32, P <. 01), and depressive symptoms (k = 7, n = 337: Hedges' g =. 71, P <. 001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g =. 32, P <. 05), while exercise in general or in any other form had no effect on cognition. Conclusion: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.",
keywords = "aerobic exercise, cognition, functioning, psychopathology, yoga",
author = "Meenakshi Dauwan and Begemann, {Marieke J H} and Heringa, {Sophie M.} and Sommer, {Iris E.}",
year = "2016",
month = "5",
day = "1",
doi = "10.1093/schbul/sbv164",
language = "English",
volume = "42",
pages = "588--599",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "3",

}

Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia : A systematic review and meta-analysis. / Dauwan, Meenakshi; Begemann, Marieke J H; Heringa, Sophie M.; Sommer, Iris E.

In: Schizophrenia Bulletin, Vol. 42, No. 3, 01.05.2016, p. 588-599.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia

T2 - A systematic review and meta-analysis

AU - Dauwan, Meenakshi

AU - Begemann, Marieke J H

AU - Heringa, Sophie M.

AU - Sommer, Iris E.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. Methods: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. Results: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g =. 39, P <. 001), positive (k = 15, n = 715: Hedges' g =. 32, P <. 01), negative (k = 18, n = 854: Hedges' g =. 49, P <. 001), and general (k = 10, n = 475: Hedges' g =. 27, P <. 05) symptoms, quality of life (k = 11, n = 770: Hedges' g =. 55, P <. 001), global functioning (k = 5, n = 342: Hedges' g =. 32, P <. 01), and depressive symptoms (k = 7, n = 337: Hedges' g =. 71, P <. 001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g =. 32, P <. 05), while exercise in general or in any other form had no effect on cognition. Conclusion: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.

AB - Background: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. Methods: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. Results: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g =. 39, P <. 001), positive (k = 15, n = 715: Hedges' g =. 32, P <. 01), negative (k = 18, n = 854: Hedges' g =. 49, P <. 001), and general (k = 10, n = 475: Hedges' g =. 27, P <. 05) symptoms, quality of life (k = 11, n = 770: Hedges' g =. 55, P <. 001), global functioning (k = 5, n = 342: Hedges' g =. 32, P <. 01), and depressive symptoms (k = 7, n = 337: Hedges' g =. 71, P <. 001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g =. 32, P <. 05), while exercise in general or in any other form had no effect on cognition. Conclusion: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.

KW - aerobic exercise

KW - cognition

KW - functioning

KW - psychopathology

KW - yoga

UR - http://www.scopus.com/inward/record.url?scp=84966263904&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbv164

DO - 10.1093/schbul/sbv164

M3 - Article

VL - 42

SP - 588

EP - 599

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 3

ER -