TY - JOUR
T1 - Exome sequencing of a large family identifies potential candidate genes contributing risk to bipolar disorder
AU - Zhang, Tianxiao
AU - Hou, Liping
AU - Chen, David T.
AU - McMahon, Francis J.
AU - Wang, Jen-Chyong
AU - Rice, John P.
PY - 2018
Y1 - 2018
N2 - Bipolar disorder is a mental illness with lifetime prevalence of about 1%. Previous genetic studies have identified multiple chromosomal linkage regions and candidate genes that might be associated with bipolar disorder. The present study aimed to identify potential susceptibility variants for bipolar disorder using 6 related case samples from a four-generation family. A combination of exome sequencing and linkage analysis was performed to identify potential susceptibility variants for bipolar disorder. Our study identified a list of five potential candidate genes for bipolar disorder. Among these five genes, GRID1(Glutamate Receptor Delta-1 Subunit), which was previously reported to be associated with several psychiatric disorders and brain related traits, is particularly interesting. Variants with functional significance in this gene were identified from two cousins in our bipolar disorder pedigree. Our findings suggest a potential role for these genes and the related rare variants in the onset and development of bipolar disorder in this one family. Additional research is needed to replicate these findings and evaluate their patho-biological significance.
AB - Bipolar disorder is a mental illness with lifetime prevalence of about 1%. Previous genetic studies have identified multiple chromosomal linkage regions and candidate genes that might be associated with bipolar disorder. The present study aimed to identify potential susceptibility variants for bipolar disorder using 6 related case samples from a four-generation family. A combination of exome sequencing and linkage analysis was performed to identify potential susceptibility variants for bipolar disorder. Our study identified a list of five potential candidate genes for bipolar disorder. Among these five genes, GRID1(Glutamate Receptor Delta-1 Subunit), which was previously reported to be associated with several psychiatric disorders and brain related traits, is particularly interesting. Variants with functional significance in this gene were identified from two cousins in our bipolar disorder pedigree. Our findings suggest a potential role for these genes and the related rare variants in the onset and development of bipolar disorder in this one family. Additional research is needed to replicate these findings and evaluate their patho-biological significance.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040608702&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29248581
U2 - 10.1016/j.gene.2017.12.025
DO - 10.1016/j.gene.2017.12.025
M3 - Article
C2 - 29248581
VL - 645
SP - 119
EP - 123
JO - Gene
JF - Gene
SN - 0378-1119
ER -