Experimental autoimmune encephalomyelitis in Primates

Paul A. Smith*, Sandra Amor, Bert A. 'Thart

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Due to their genetic and immunological proximity to humans, the common marmoset, Callithrix jacchus, provides an important bridge between rodent-based research and the human disease. Experimental autoimmune encephalomyelitis (EAE) induced in the outbred common marmoset provides a highly reproducible model of multiple sclerosis (MS) phenotypically characterised by neurological deficits, inflammatory lesions of the cerebral white matter and spinal cord, primary demyelination and axonal destruction. A fused placental blood circulation in utero, unique amongst monkeys, results in an immune tolerance between chimeric twins which allows adoptive transfer experiments assessing the relative contributions of T- and B-cells to pathogenesis. Overall, the ability to perform serial blood sampling, quantitative magnetic resonance imaging (MRI) and histopathological techniques, which are comparable to the human MS situation, means that the common marmoset EAE model provides an excellent test system for investigating the relationship between neurological deficits and pathological processes and the evaluation of new therapeutics.

Original languageEnglish
Title of host publicationExperimental Models of Multiple Sclerosis
PublisherSpringer US
Pages561-576
Number of pages16
ISBN (Electronic)9780387255187
ISBN (Print)0387255176, 9780387255170
DOIs
Publication statusPublished - 1 Jan 2005

Cite this

Smith, P. A., Amor, S., & 'Thart, B. A. (2005). Experimental autoimmune encephalomyelitis in Primates. In Experimental Models of Multiple Sclerosis (pp. 561-576). Springer US. https://doi.org/10.1007/0-387-25518-4_27