Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice

N E Preece, S Amor, D Baker, D G Gadian, J K O'Neill, J Urenjak

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.

Original languageEnglish
Pages (from-to)692-7
Number of pages6
JournalMagnetic Resonance in Medicine
Volume32
Issue number6
Publication statusPublished - Dec 1994

Cite this

Preece, N. E., Amor, S., Baker, D., Gadian, D. G., O'Neill, J. K., & Urenjak, J. (1994). Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice. Magnetic Resonance in Medicine, 32(6), 692-7.