Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice

N E Preece, S Amor, D Baker, D G Gadian, J K O'Neill, J Urenjak

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In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.

Original languageEnglish
Pages (from-to)692-7
Number of pages6
JournalMagnetic Resonance in Medicine
Issue number6
Publication statusPublished - Dec 1994

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