Explaining unexplained hypoglycemia: How LC-MS/MS can help

M. T. Ackermans; J. Hopman; A. C. Heijboer; S. E. Siegelaar

doi:10.1016/j.plabm.2022.e00291

Explaining unexplained hypoglycemia: How LC-MS/MS can help

M. T. Ackermans^*, J. Hopman, A. C. Heijboer, S. E. Siegelaar

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened.

Original language	English
Article number	e00291
Journal	Practical Laboratory Medicine
Volume	31
DOIs	https://doi.org/10.1016/j.plabm.2022.e00291
Publication status	Published - 1 Aug 2022

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abstract = "Explaining hypoglycaemia, especially in patients without diabetes mellitus, is challenging. Here we present a case, where the added value for clinical diagnosis of insulin determination with liquid chromatography-mass spectrometry (LC-MS/MS) is shown. By the use of LC-MS/MS the different insulin analogues can be identified. The confirmation of an insulin analogue present during hypoglycaemia facilitated in our case the discussion with the patient and his family about what happened.",

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Explaining unexplained hypoglycemia: How LC-MS/MS can help

Abstract

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