TY - JOUR
T1 - Exploración de la red cerebral
T2 - una revisión de la conectividad funcional en la RMf en estado de reposo
AU - Van Den Heuvel, Martijn P.
AU - Pol, Hilleke E.Hulshoff
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Our brain is a network. It consists of spatially distributed, but functionally linked regions that continuously share information with each other. Interestingly, recent advances in the acquisitionand analysis of functional neuroimaging data have catalyzed the exploration of functional connectivity in the human brain. Functional connectivity is defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions and in the past years an increasing body of neuroimaging studies has started to explore functional connectivity by measuring the level of co-activation of resting-state fMRI time-series between brain regions. These studies have revealed interesting new findings about the functional connections of specific brain regions and local networks, as well as important new insights in the overall organization of functional communication in the brain network. Here we present an overview of these new methods and discuss how they have led to new insights in core aspects of the human brain, providing an overview of these novel imaging techniques and their implication to neuroscience. We discuss the use of spontaneous resting-state fMRI in determining functional connectivity, discuss suggested origins of these signals, how functional connections tend to be related to structural connections in the brain network and how functional brain communication may form a key role in cognitive performance. Furthermore, we will discuss the upcoming field of examining functional connectivity patterns using graph theory, focusing on the overall organization of the functional brain network. Specifically, we will discuss the value of these new functional connectivity tools in examining believed connectivity diseases, like Alzheimer's disease, dementia, schizophrenia and multiple sclerosis.
AB - Our brain is a network. It consists of spatially distributed, but functionally linked regions that continuously share information with each other. Interestingly, recent advances in the acquisitionand analysis of functional neuroimaging data have catalyzed the exploration of functional connectivity in the human brain. Functional connectivity is defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions and in the past years an increasing body of neuroimaging studies has started to explore functional connectivity by measuring the level of co-activation of resting-state fMRI time-series between brain regions. These studies have revealed interesting new findings about the functional connections of specific brain regions and local networks, as well as important new insights in the overall organization of functional communication in the brain network. Here we present an overview of these new methods and discuss how they have led to new insights in core aspects of the human brain, providing an overview of these novel imaging techniques and their implication to neuroscience. We discuss the use of spontaneous resting-state fMRI in determining functional connectivity, discuss suggested origins of these signals, how functional connections tend to be related to structural connections in the brain network and how functional brain communication may form a key role in cognitive performance. Furthermore, we will discuss the upcoming field of examining functional connectivity patterns using graph theory, focusing on the overall organization of the functional brain network. Specifically, we will discuss the value of these new functional connectivity tools in examining believed connectivity diseases, like Alzheimer's disease, dementia, schizophrenia and multiple sclerosis.
KW - Anatomical connectivity
KW - Complex systems
KW - Complexity
KW - Diffusion tensor imaging
KW - Diffusion tensor imaging (DTI)
KW - Functional brain networks
KW - Functional connectivity
KW - Functional magnetic resonance imaging (fMRI)
KW - Graph analysis
KW - Network
KW - Network analysis
KW - Resting-state connectivity
KW - Resting-state fMRI
KW - Review
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=79960834247&partnerID=8YFLogxK
U2 - 10.1016/j.psiq.2011.05.001
DO - 10.1016/j.psiq.2011.05.001
M3 - Short survey
AN - SCOPUS:79960834247
VL - 18
SP - 28
EP - 41
JO - Psiquiatria Biologica
JF - Psiquiatria Biologica
SN - 1134-5934
IS - 1
ER -