Expression of Leu-7 in myocardial sleeves around human pulmonary veins

Ivana Kholová, Hans W M Niessen, Josef Kautzner

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Atrial fibrillation (AF) is the most common sustained clinical arrhythmia. Myocardial sleeves onto pulmonary veins (PVs) have been recognized as a frequent site of origin of focal triggers for this arrhythmia. Expression of Leu-7 has been hypothesized to correspond with abnormal atrial automaticity.

OBJECTIVE: To evaluate a possible role of the Leu-7 immunoreactivity in AF patients, we studied Leu-7 expression in myocardial sleeves.

METHODS: Leu-7 was studied immunohistochemically in paraffin-embedded specimens from 55 human autopsied hearts (mean age 69 years, range 42-94 years, 34 males, 21 females). Twenty-two of the subjects had previous history of AF.

RESULTS: Myocardial sleeves were found in 151 out of a total number of 220 PVs (68.6%). Leu-7 granular cytoplasmatic positivity was observed in 15 (9.9%) PVs from 12 different hearts: 6 (15.4%) in the right superior, 4 (10.2%) in the right inferior, 4 (10.8%) in the left superior and 1 (2.7%) in the left inferior PV. This finding was revealed both in patients with and without the history of AF.

CONCLUSIONS: Leu-7 positivity, hypothesized to correspond with abnormal atrial automaticity, can be detected in some myocardial sleeves around PVs. However, no statistical relationship to previous history of AF was found.

Original languageEnglish
Pages (from-to)263-6
Number of pages4
JournalCardiovascular Pathology
Volume12
Issue number5
Publication statusPublished - 26 Sep 2003

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