Extracellular vesicle-based nucleic acid delivery: Current advances and future perspectives in cancer therapeutic strategies

Crescenzo Massaro, Giulia Sgueglia, Victoria Frattolillo, S. Rubina Baglio, Lucia Altucci*, Carmela Dell’aversana

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


Extracellular vesicles (EVs) are sophisticated and sensitive messengers released by cells to communicate with and influence distant and neighboring cells via selective transfer of bioactive content, including protein lipids and nucleic acids. EVs have therefore attracted broad interest as new and refined potential therapeutic systems in many diseases, including cancer, due to their low immunogenicity, non-toxicity, and elevated bioavailability. They might serve as safe and effective vehicles for the transport of therapeutic molecules to specific tissues and cells. In this review, we focus on EVs as a vehicle for gene therapy in cancer. We describe recent developments in EV engineering to achieve efficient intracellular delivery of cancer therapeutics and avoid off-target effects, to provide an overview of the potential applications of EV-mediated gene therapy and the most promising biomedical advances.

Original languageEnglish
Article number980
Pages (from-to)1-19
Number of pages19
Issue number10
Publication statusPublished - Oct 2020

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