Eye size in retinoblastoma: MR imaging measurements in normal and affected eyes

Pim de Graaf, Dirk L Knol, Annette C Moll, Saskia M Imhof, Antoinette Y N Schouten-van Meeteren, Jonas A Castelijns

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To evaluate eye size retrospectively by using magnetic resonance (MR) imaging to measure axial length (AL), equatorial diameter (ED), and eye volume (EV) in patients with retinoblastoma and to evaluate the possible effect of retinoblastoma on eye size.

MATERIALS AND METHODS: Local ethics committee approval was obtained with waiver of informed consent. MR images of 100 patients with retinoblastoma (50 girls, 50 boys; mean age, 19 months; age range, 9 days to 68 months) were scored by one observer (AL, ED, EV, and tumor volume measurements), with a second observer reviewing all measurements. Normal eyes of patients with unilateral retinoblastoma served as controls. Interobserver measurement agreement was evaluated in a random subset of 50 eyes with use of intraclass correlation coefficients. Linear mixed model analysis was used with adjustments for age, laterality, and sex.

RESULTS: Interobserver agreement was good (intraclass correlation coefficients >or= 0.89). Eyes with retinoblastoma had significantly shorter ALs (95% confidence interval [CI]: -0.57 mm, -0.16 mm; P=.001) and EDs (95% CI: -1.01 mm, -0.66 mm; P<.001) and significantly smaller EVs (95% CI: -336 mm(3), -151 mm(3); P<.001) than normal eyes. Within patients, a significant negative relationship was found between tumor volume and EV (P<.001).

CONCLUSION: MR imaging measurements of AL, ED, and EV were significantly smaller in eyes with retinoblastoma than in normal eyes. In addition, in patients with retinoblastoma, the larger the tumor volume, the smaller the eye.

Original languageEnglish
Pages (from-to)273-80
Number of pages8
JournalRadiology
Volume244
Issue number1
DOIs
Publication statusPublished - Jul 2007

Cite this

de Graaf, Pim ; Knol, Dirk L ; Moll, Annette C ; Imhof, Saskia M ; Schouten-van Meeteren, Antoinette Y N ; Castelijns, Jonas A. / Eye size in retinoblastoma : MR imaging measurements in normal and affected eyes. In: Radiology. 2007 ; Vol. 244, No. 1. pp. 273-80.
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abstract = "PURPOSE: To evaluate eye size retrospectively by using magnetic resonance (MR) imaging to measure axial length (AL), equatorial diameter (ED), and eye volume (EV) in patients with retinoblastoma and to evaluate the possible effect of retinoblastoma on eye size.MATERIALS AND METHODS: Local ethics committee approval was obtained with waiver of informed consent. MR images of 100 patients with retinoblastoma (50 girls, 50 boys; mean age, 19 months; age range, 9 days to 68 months) were scored by one observer (AL, ED, EV, and tumor volume measurements), with a second observer reviewing all measurements. Normal eyes of patients with unilateral retinoblastoma served as controls. Interobserver measurement agreement was evaluated in a random subset of 50 eyes with use of intraclass correlation coefficients. Linear mixed model analysis was used with adjustments for age, laterality, and sex.RESULTS: Interobserver agreement was good (intraclass correlation coefficients >or= 0.89). Eyes with retinoblastoma had significantly shorter ALs (95{\%} confidence interval [CI]: -0.57 mm, -0.16 mm; P=.001) and EDs (95{\%} CI: -1.01 mm, -0.66 mm; P<.001) and significantly smaller EVs (95{\%} CI: -336 mm(3), -151 mm(3); P<.001) than normal eyes. Within patients, a significant negative relationship was found between tumor volume and EV (P<.001).CONCLUSION: MR imaging measurements of AL, ED, and EV were significantly smaller in eyes with retinoblastoma than in normal eyes. In addition, in patients with retinoblastoma, the larger the tumor volume, the smaller the eye.",
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Eye size in retinoblastoma : MR imaging measurements in normal and affected eyes. / de Graaf, Pim; Knol, Dirk L; Moll, Annette C; Imhof, Saskia M; Schouten-van Meeteren, Antoinette Y N; Castelijns, Jonas A.

In: Radiology, Vol. 244, No. 1, 07.2007, p. 273-80.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Eye size in retinoblastoma

T2 - MR imaging measurements in normal and affected eyes

AU - de Graaf, Pim

AU - Knol, Dirk L

AU - Moll, Annette C

AU - Imhof, Saskia M

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N2 - PURPOSE: To evaluate eye size retrospectively by using magnetic resonance (MR) imaging to measure axial length (AL), equatorial diameter (ED), and eye volume (EV) in patients with retinoblastoma and to evaluate the possible effect of retinoblastoma on eye size.MATERIALS AND METHODS: Local ethics committee approval was obtained with waiver of informed consent. MR images of 100 patients with retinoblastoma (50 girls, 50 boys; mean age, 19 months; age range, 9 days to 68 months) were scored by one observer (AL, ED, EV, and tumor volume measurements), with a second observer reviewing all measurements. Normal eyes of patients with unilateral retinoblastoma served as controls. Interobserver measurement agreement was evaluated in a random subset of 50 eyes with use of intraclass correlation coefficients. Linear mixed model analysis was used with adjustments for age, laterality, and sex.RESULTS: Interobserver agreement was good (intraclass correlation coefficients >or= 0.89). Eyes with retinoblastoma had significantly shorter ALs (95% confidence interval [CI]: -0.57 mm, -0.16 mm; P=.001) and EDs (95% CI: -1.01 mm, -0.66 mm; P<.001) and significantly smaller EVs (95% CI: -336 mm(3), -151 mm(3); P<.001) than normal eyes. Within patients, a significant negative relationship was found between tumor volume and EV (P<.001).CONCLUSION: MR imaging measurements of AL, ED, and EV were significantly smaller in eyes with retinoblastoma than in normal eyes. In addition, in patients with retinoblastoma, the larger the tumor volume, the smaller the eye.

AB - PURPOSE: To evaluate eye size retrospectively by using magnetic resonance (MR) imaging to measure axial length (AL), equatorial diameter (ED), and eye volume (EV) in patients with retinoblastoma and to evaluate the possible effect of retinoblastoma on eye size.MATERIALS AND METHODS: Local ethics committee approval was obtained with waiver of informed consent. MR images of 100 patients with retinoblastoma (50 girls, 50 boys; mean age, 19 months; age range, 9 days to 68 months) were scored by one observer (AL, ED, EV, and tumor volume measurements), with a second observer reviewing all measurements. Normal eyes of patients with unilateral retinoblastoma served as controls. Interobserver measurement agreement was evaluated in a random subset of 50 eyes with use of intraclass correlation coefficients. Linear mixed model analysis was used with adjustments for age, laterality, and sex.RESULTS: Interobserver agreement was good (intraclass correlation coefficients >or= 0.89). Eyes with retinoblastoma had significantly shorter ALs (95% confidence interval [CI]: -0.57 mm, -0.16 mm; P=.001) and EDs (95% CI: -1.01 mm, -0.66 mm; P<.001) and significantly smaller EVs (95% CI: -336 mm(3), -151 mm(3); P<.001) than normal eyes. Within patients, a significant negative relationship was found between tumor volume and EV (P<.001).CONCLUSION: MR imaging measurements of AL, ED, and EV were significantly smaller in eyes with retinoblastoma than in normal eyes. In addition, in patients with retinoblastoma, the larger the tumor volume, the smaller the eye.

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KW - Female

KW - Gadolinium DTPA

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Linear Models

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Reproducibility of Results

KW - Retinal Neoplasms/pathology

KW - Retinoblastoma/pathology

KW - Retrospective Studies

U2 - 10.1148/radiol.2441060456

DO - 10.1148/radiol.2441060456

M3 - Article

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