TY - JOUR
T1 - Factors associated with the development of pneumocystis carinii pneumonia in 5,025 european patients withaids
AU - Lundgren, J. D.
AU - Barton, S. E.
AU - Lazzarin, A.
AU - Danner, S.
AU - Goebel, F. D.
AU - Pehrson, P.
AU - Mulcahy, F.
AU - Kosmidis, J.
AU - Pedersen, C.
AU - Phillips, A. N.
PY - 1995/7
Y1 - 1995/7
N2 - This study examined the factors associated with the development of a first episode of Pneumocystis carinii pneumonia (PCP) in 5,025 patients with AIDS, including 1,976 patients with primary PCP at the time of AIDS diagnosis and 635with primary PCP occurring subsequently. Compared with untreated patients, patients treated withzidovudine were at similar risk of developing PCP during the first year of therapy but were at greater risk after longer intervals of treatment The following factors were associated with an increased risk of PCP (either at the time of AIDS diagnosis or thereafter): lack of primary PCP prophylaxis, male homosexualitylbisexuality, diagnosis of AIDS in northern Europe, and CD4 cell count below 200 × 106/L at the time of AIDS diagnosis. Patients with severe weight loss had a 60% higher risk of developing PCP during follow-up than those without such weight loss. Thus, the occurrence of PCP depended on geographic location, mode of acquisition o human immunodeficiency virus and AIDS, degree ofimmunodeficiency, and use of various treatment regimens.
AB - This study examined the factors associated with the development of a first episode of Pneumocystis carinii pneumonia (PCP) in 5,025 patients with AIDS, including 1,976 patients with primary PCP at the time of AIDS diagnosis and 635with primary PCP occurring subsequently. Compared with untreated patients, patients treated withzidovudine were at similar risk of developing PCP during the first year of therapy but were at greater risk after longer intervals of treatment The following factors were associated with an increased risk of PCP (either at the time of AIDS diagnosis or thereafter): lack of primary PCP prophylaxis, male homosexualitylbisexuality, diagnosis of AIDS in northern Europe, and CD4 cell count below 200 × 106/L at the time of AIDS diagnosis. Patients with severe weight loss had a 60% higher risk of developing PCP during follow-up than those without such weight loss. Thus, the occurrence of PCP depended on geographic location, mode of acquisition o human immunodeficiency virus and AIDS, degree ofimmunodeficiency, and use of various treatment regimens.
UR - http://www.scopus.com/inward/record.url?scp=0029039521&partnerID=8YFLogxK
U2 - 10.1093/clinids/21.1.106
DO - 10.1093/clinids/21.1.106
M3 - Article
C2 - 7578718
AN - SCOPUS:0029039521
VL - 21
SP - 106
EP - 113
JO - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
SN - 1058-4838
IS - 1
ER -