Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees; C. Sewing; M. J.W.D. Vosjan; V. Tadino; J. D.M. Herscheid; A. D. Windhorst; D. J. Vugts

doi:10.1039/c8cc03206h

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees^*, C. Sewing, M. J.W.D. Vosjan, V. Tadino, J. D.M. Herscheid, A. D. Windhorst, D. J. Vugts

^*Corresponding author for this work

Radiology and nuclear medicine

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A novel strategy for the production of reactive [¹⁸F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [¹⁸F]triflyl fluoride is formed instantaneously at room temperature from hydrated [¹⁸F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [¹⁸F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [¹⁸F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [¹⁸F]fluoroestradiol ([¹⁸F]FES) and O-2-[¹⁸F]fluoroethyl-l-tyrosine ([¹⁸F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol⁻¹.

Original language	English
Pages (from-to)	10179-10182
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	72
DOIs	https://doi.org/10.1039/c8cc03206h
Publication status	Published - 6 Sept 2018

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title = "Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source",

abstract = "A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-l-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.",

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doi = "10.1039/c8cc03206h",

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T1 - Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

AU - Pees, A.

AU - Sewing, C.

AU - Vosjan, M. J.W.D.

AU - Tadino, V.

AU - Herscheid, J. D.M.

AU - Windhorst, A. D.

AU - Vugts, D. J.

PY - 2018/9/6

Y1 - 2018/9/6

N2 - A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-l-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

AB - A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-l-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

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JO - Chemical Commununications

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IS - 72

ER -

Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

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