Fast and reliable generation of [18F]triflyl fluoride, a gaseous [18F]fluoride source

A. Pees*, C. Sewing, M. J.W.D. Vosjan, V. Tadino, J. D.M. Herscheid, A. D. Windhorst, D. J. Vugts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


A novel strategy for the production of reactive [18F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [18F]triflyl fluoride is formed instantaneously at room temperature from hydrated [18F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [18F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [18F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [18F]fluoroestradiol ([18F]FES) and O-2-[18F]fluoroethyl-l-tyrosine ([18F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol−1.

Original languageEnglish
Pages (from-to)10179-10182
Number of pages4
JournalChemical Communications
Issue number72
Publication statusPublished - 6 Sept 2018

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