TY - JOUR
T1 - Fast T2 mapping using multi-echo spin-echo MRI
T2 - A linear order approach
AU - Fatemi, Yaghoub
AU - Danyali, Habibollah
AU - Helfroush, Mohammad Sadegh
AU - Amiri, Houshang
N1 - Funding Information:
The authors thank Zahra Sharifi for significant assistance with data collection and Zahra Farshidfar for valuable discussions at the early stage of the research.
Publisher Copyright:
© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Purpose: Multi-echo spin-echo sequence is commonly used for T2 mapping. The estimated values using conventional exponential fit, however, are hampered by stimulated and indirect echoes leading to overestimation of T2. Here, we present fast analysis of multi-echo spin-echo (FAMESE) as a novel approach to decrease the complexity of the search space, which leads to accelerated measurement of T2. Methods: We developed FAMESE based on mathematical analysis of the Bloch equations in which the search space dimension decreased to only one. Then, we tested it in both phantom and human brain. Bland-Altman plot was used to assess the agreement between the estimated T2 values from FAMESE and the ones estimated from single-echo spin-echo sequence. The reliability of FAMESE was assessed by intraclass correlation coefficients. In addition, we investigated the noise stability of the method in synthetic and experimental data. Results: In both phantom and healthy participants, FAMESE provided accelerated and SNR-resistant T2 maps. The FAMESE had a very good agreement with the single-echo spin echo for the whole range of T2 values. The intraclass correlation coefficient values for FAMESE were excellent (ie, 0.9998 and 0.9860 < intraclass correlation coefficient < 0.9942 for the phantom and humans, respectively). Conclusion: Our developed method FAMESE could be considered as a candidate for rapid T2 mapping with a clinically feasible scan time.
AB - Purpose: Multi-echo spin-echo sequence is commonly used for T2 mapping. The estimated values using conventional exponential fit, however, are hampered by stimulated and indirect echoes leading to overestimation of T2. Here, we present fast analysis of multi-echo spin-echo (FAMESE) as a novel approach to decrease the complexity of the search space, which leads to accelerated measurement of T2. Methods: We developed FAMESE based on mathematical analysis of the Bloch equations in which the search space dimension decreased to only one. Then, we tested it in both phantom and human brain. Bland-Altman plot was used to assess the agreement between the estimated T2 values from FAMESE and the ones estimated from single-echo spin-echo sequence. The reliability of FAMESE was assessed by intraclass correlation coefficients. In addition, we investigated the noise stability of the method in synthetic and experimental data. Results: In both phantom and healthy participants, FAMESE provided accelerated and SNR-resistant T2 maps. The FAMESE had a very good agreement with the single-echo spin echo for the whole range of T2 values. The intraclass correlation coefficient values for FAMESE were excellent (ie, 0.9998 and 0.9860 < intraclass correlation coefficient < 0.9942 for the phantom and humans, respectively). Conclusion: Our developed method FAMESE could be considered as a candidate for rapid T2 mapping with a clinically feasible scan time.
KW - extended phase graph
KW - indirect echoes
KW - magnetic resonance imaging
KW - stimulated echoes
KW - T relaxation time
UR - http://www.scopus.com/inward/record.url?scp=85085578410&partnerID=8YFLogxK
U2 - 10.1002/mrm.28309
DO - 10.1002/mrm.28309
M3 - Article
C2 - 32430979
AN - SCOPUS:85085578410
VL - 84
SP - 2815
EP - 2830
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 5
ER -