Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women

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Abstract

The purpose of this study was to analyze the longitudinal relationship between body composition and lumbar bone mineral density (LBMD) and lumbar bone mineral content (LBMC) in (young) adults over a 10-yr period. The data are from the Amsterdam Growth and Health Longitudinal Study. Two hundred twenty-five men and 241 women were measured at 27, 32, and/or 36 yr of age. Nine body composition components were explored: total body weight, standing height, body mass index, waist circumference, hip circumference, waist to hip ratio, sum of four skinfolds, fat mass, and fat-free mass (FFM). Stratified analyses were performed by gender and adjustment was made for physical activity and calcium intake. Univariate multilevel analyses indicated that FFM was significantly positively related to the 10-yr development of both LBMD and LBMC in both sexes. Total body weight, standing height, and body mass index also showed a significant positive univariate relationships with LBMD and LBMC in both sexes, fat mass only with female LBMD. All best predictive multiple regression models included FFM, explaining 4-27% of the variation in bone mineral over this 10-yr period. Because FFM can be interpreted as a proxy for skeletal muscle mass, these results indicate the importance of muscle contractions on bone to increase bone strength in (young) adults.

Original languageEnglish
Pages (from-to)2607-13
Number of pages7
JournalThe Journal of clinical endocrinology and metabolism
Volume88
Issue number6
DOIs
Publication statusPublished - Jun 2003

Cite this

@article{129a3a786b54466391875d37f741c0d5,
title = "Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women",
abstract = "The purpose of this study was to analyze the longitudinal relationship between body composition and lumbar bone mineral density (LBMD) and lumbar bone mineral content (LBMC) in (young) adults over a 10-yr period. The data are from the Amsterdam Growth and Health Longitudinal Study. Two hundred twenty-five men and 241 women were measured at 27, 32, and/or 36 yr of age. Nine body composition components were explored: total body weight, standing height, body mass index, waist circumference, hip circumference, waist to hip ratio, sum of four skinfolds, fat mass, and fat-free mass (FFM). Stratified analyses were performed by gender and adjustment was made for physical activity and calcium intake. Univariate multilevel analyses indicated that FFM was significantly positively related to the 10-yr development of both LBMD and LBMC in both sexes. Total body weight, standing height, and body mass index also showed a significant positive univariate relationships with LBMD and LBMC in both sexes, fat mass only with female LBMD. All best predictive multiple regression models included FFM, explaining 4-27{\%} of the variation in bone mineral over this 10-yr period. Because FFM can be interpreted as a proxy for skeletal muscle mass, these results indicate the importance of muscle contractions on bone to increase bone strength in (young) adults.",
keywords = "Adipose Tissue/anatomy & histology, Adult, Body Composition, Body Constitution, Body Height, Body Weight, Bone Density, Bone Development, Female, Humans, Longitudinal Studies, Lumbar Vertebrae/growth & development, Male, Organ Size, Skinfold Thickness",
author = "Ingrid Bakker and Twisk, {Jos W R} and {Van Mechelen}, Willem and Kemper, {Han C G}",
year = "2003",
month = "6",
doi = "10.1210/jc.2002-021538",
language = "English",
volume = "88",
pages = "2607--13",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women

AU - Bakker, Ingrid

AU - Twisk, Jos W R

AU - Van Mechelen, Willem

AU - Kemper, Han C G

PY - 2003/6

Y1 - 2003/6

N2 - The purpose of this study was to analyze the longitudinal relationship between body composition and lumbar bone mineral density (LBMD) and lumbar bone mineral content (LBMC) in (young) adults over a 10-yr period. The data are from the Amsterdam Growth and Health Longitudinal Study. Two hundred twenty-five men and 241 women were measured at 27, 32, and/or 36 yr of age. Nine body composition components were explored: total body weight, standing height, body mass index, waist circumference, hip circumference, waist to hip ratio, sum of four skinfolds, fat mass, and fat-free mass (FFM). Stratified analyses were performed by gender and adjustment was made for physical activity and calcium intake. Univariate multilevel analyses indicated that FFM was significantly positively related to the 10-yr development of both LBMD and LBMC in both sexes. Total body weight, standing height, and body mass index also showed a significant positive univariate relationships with LBMD and LBMC in both sexes, fat mass only with female LBMD. All best predictive multiple regression models included FFM, explaining 4-27% of the variation in bone mineral over this 10-yr period. Because FFM can be interpreted as a proxy for skeletal muscle mass, these results indicate the importance of muscle contractions on bone to increase bone strength in (young) adults.

AB - The purpose of this study was to analyze the longitudinal relationship between body composition and lumbar bone mineral density (LBMD) and lumbar bone mineral content (LBMC) in (young) adults over a 10-yr period. The data are from the Amsterdam Growth and Health Longitudinal Study. Two hundred twenty-five men and 241 women were measured at 27, 32, and/or 36 yr of age. Nine body composition components were explored: total body weight, standing height, body mass index, waist circumference, hip circumference, waist to hip ratio, sum of four skinfolds, fat mass, and fat-free mass (FFM). Stratified analyses were performed by gender and adjustment was made for physical activity and calcium intake. Univariate multilevel analyses indicated that FFM was significantly positively related to the 10-yr development of both LBMD and LBMC in both sexes. Total body weight, standing height, and body mass index also showed a significant positive univariate relationships with LBMD and LBMC in both sexes, fat mass only with female LBMD. All best predictive multiple regression models included FFM, explaining 4-27% of the variation in bone mineral over this 10-yr period. Because FFM can be interpreted as a proxy for skeletal muscle mass, these results indicate the importance of muscle contractions on bone to increase bone strength in (young) adults.

KW - Adipose Tissue/anatomy & histology

KW - Adult

KW - Body Composition

KW - Body Constitution

KW - Body Height

KW - Body Weight

KW - Bone Density

KW - Bone Development

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Lumbar Vertebrae/growth & development

KW - Male

KW - Organ Size

KW - Skinfold Thickness

U2 - 10.1210/jc.2002-021538

DO - 10.1210/jc.2002-021538

M3 - Article

VL - 88

SP - 2607

EP - 2613

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -