Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

M. J.B. Taphoorn; E. van Someren; F. J. Snoek; R. L.M. Strijers; D. F. Swaab; F. Visscher; L. P. de Waal; C. H. Polman

doi:10.1007/BF00867360

Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

M. J.B. Taphoorn^*, E. van Someren, F. J. Snoek, R. L.M. Strijers, D. F. Swaab, F. Visscher, L. P. de Waal, C. H. Polman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.

Original language	English
Pages (from-to)	446-448
Number of pages	3
Journal	Journal of Neurology
Volume	240
Issue number	7
DOIs	https://doi.org/10.1007/BF00867360
Publication status	Published - 1 Jul 1993

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10.1007/BF00867360

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title = "Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis",

abstract = "The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.",

keywords = "Circadian rhythm, Fatigue, Multiple sclerosis, Sleep",

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AU - Taphoorn, M. J.B.

AU - van Someren, E.

AU - Snoek, F. J.

AU - Strijers, R. L.M.

AU - Swaab, D. F.

AU - Visscher, F.

AU - de Waal, L. P.

AU - Polman, C. H.

PY - 1993/7/1

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AB - The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.

KW - Circadian rhythm

KW - Fatigue

KW - Multiple sclerosis

KW - Sleep

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Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

Abstract

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