Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts

C. S. Thesing*, A. Lok, Y. Milaneschi, J. Assies, C. L.H. Bockting, C. A. Figueroa, E. J. Giltay, B. W.J.H. Penninx, H. G. Ruhé, A. H. Schene, M. Bot, R. J.T. Mocking

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) alterations in patients with major depressive disorder (MDD) have been shown to persist after remission. Whether these alterations are risk factors for MDD recurrence remains unknown. Here, we examined whether fatty acids predict time until MDD recurrence in remitted MDD patients. Methods: Data were used from remitted MDD patients of the Netherlands Study of Depression and Anxiety (n = 356) and the Depression Evaluation Longitudinal Therapy Assessment studies (n = 118). Associations of FAs with time until MDD recurrence up to 8-year follow-up were analyzed using Cox regression analyses. Study-specific estimates were pooled using mega- and meta-analysis techniques. Results: 27.5% (NESDA) and 56.8% (DELTA) participants had an MDD recurrence. Pooled results showed that no FA was significantly associated with time until MDD recurrence (n-3 PUFAs: hazard ratio (HR) = 1.17, 95% confidence interval (CI) = 0.98–1.41, P = 0.082; n-6 PUFAs: HR = 1.08, 95% CI = 0.84–1.38, P = 0.55). Conclusion: In remitted MDD patients, circulating PUFAs were not associated with prospective risk of MDD recurrence. Consequently, circulating PUFAs are unlikely to reflect a vulnerability marker for recurrence, so correcting n-3 PUFA ‘deficits’ through supplementation does not seem a promising option to prevent MDD recurrence.

Original languageEnglish
Pages (from-to)362-373
Number of pages12
JournalActa Psychiatrica Scandinavica
Issue number4
Early online date1 Jan 2019
Publication statusPublished - 1 Apr 2020

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