Feasibility of a supervised and home-based tailored exercise intervention in head and neck cancer patients during chemoradiotherapy

Annemieke Kok*, Ellen Passchier, Anne M. May, Michiel W. M. van den Brekel, Harriët Jager-Wittenaar, Cindy Veenhof, Remco de Bree, Martijn M. Stuiver, Caroline M. Speksnijder

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: Chemoradiotherapy (CRT) for head and neck cancer (HNC) is associated with high toxicity that adversely affects physical functioning, body composition, fatigue, quality of life and treatment outcomes. Exercise interventions during treatment might counteract these negative effects. We therefore assessed the feasibility of an exercise programme for HNC patients during CRT. Methods: Forty patients were offered a tailored 10-week endurance and resistance training with supervised and home-based sessions. Feasibility endpoints were (1) adherence (main outcome): ≥60% attendance; (2) recruitment: ≥30%; (3) retention rate: ≥85% and (4) compliance rate: ≥60%. Physical performance, muscle strength, body composition, quality of life and fatigue were assessed pre- and post-intervention. Results: Overall adherence was 54%. The recruitment rate was 36%, and the retention rate was 65%. Compliance to the supervised intervention protocol was 66%. Statistically significant decreases were found in mean grip strength, fat-free mass and clinically relevant deteriorations on several domains of quality of life, and fatigue subscales were found. Conclusion: We conclude that this exercise programme for HNC patients during CRT in its current form is feasible for only a minority of patients. We suggest adaptations to improve adherence and retention rates for a definitive multicentre trial. Trial registration: This study is registered at the Netherlands Trial Register (NTR7305), 6 June 2018, retrospectively registered.
Original languageEnglish
Article numbere13662
JournalEuropean Journal of Cancer Care
Issue number6
Early online date2022
Publication statusPublished - Nov 2022
Externally publishedYes

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