FGFR3 and P53 Characterize Alternative Genetic Pathways in the Pathogenesis of Urothelial Cell Carcinoma

Bas W.G. Van Rhijn, Theo H. Van Der Kwast, André N. Vis, Wim J. Kirkels, Egbert R. Boevé, Adriaan C. Jöbsis, Ellen C. Zwarthoff*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. We here describe the distribution of FGFR3 mutations and P53 overexpression in 260 primary urothelial cell carcinomas. FGFR3 mutations were observed in 59% and P53 overexpression in 25%. Interestingly, FGFR3 and P53 alterations were mutually exclusive, because they coincided in only 5.7% of tumors. Consequently, we propose that they characterize two alternative genetic pathways in urothelial cell carcinoma pathogenesis. The genetic alterations were reflected in the pathology and the clinical outcome, i.e., FGFR3 mutations were found in low-stage/-grade tumors and were associated with a favorable disease course, whereas P53 alterations were tied to adverse disease parameters.

Original languageEnglish
Pages (from-to)1911-1914
Number of pages4
JournalCancer Research
Volume64
Issue number6
DOIs
Publication statusPublished - 15 Mar 2004

Cite this