Flucloxacillin results in suboptimal plasma voriconazole concentrations

Eline W. Muilwijk*, Bart G.J. Dekkers, Stefanie S.V. Henriet, Paul E. Verweij, Bregje Witjes, Astrid M.L. Oude Lashof, Geert H. Groeneveld, Johannes Van Der Hoeven, Jan Willem C. Alffenaar, Frans G.M. Russel, Frank Van De Veerdonk, Roger J.M. Brüggemann

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.

Original languageEnglish
Article numbere00915-17
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Cite this

Muilwijk, E. W., Dekkers, B. G. J., Henriet, S. S. V., Verweij, P. E., Witjes, B., Oude Lashof, A. M. L., ... Brüggemann, R. J. M. (2017). Flucloxacillin results in suboptimal plasma voriconazole concentrations. Antimicrobial Agents and Chemotherapy, 61(9), [e00915-17]. https://doi.org/10.1128/AAC.00915-17