Frequency and predictors of a high clinical response in patients with psoriasis on biological therapy in daily practice: results from the prospective, multicenter BioCAPTURE cohort

J. Zweegers, B. Roosenboom, P. C.M. van de Kerkhof, J. M.P.A. van den Reek, M. E. Otero, S. Atalay, A. L.A. Kuijpers, M. I.A. Koetsier, W. P. Arnold, M. A. Berends, L. Weppner-Parren, M. Bijen, M. D. Njoo, J. M. Mommers, P. P.M. van Lümig, R. J.B. Driessen, W. Kievit, E. M.G.J. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: It is important to assess which patients with psoriasis are more likely to achieve high clinical responses on biologics. Objectives: To assess the number of treatment episodes (TEs) that achieve a 100% improvement in Psoriasis Area and Severity Index (PASI 100), PASI 90 or PASI ≤ 5 at week 24 of biological treatment, and which baseline patient characteristics predict treatment response. Methods: Data from patients with psoriasis treated with adalimumab, etanercept, infliximab or ustekinumab were extracted from a prospective cohort. TEs with high clinical responses were described. Uni- and multivariate regression analyses were performed with the generalized estimating equation method to elucidate which baseline patient characteristics were predictors for PASI 90 and PASI ≤ 5 at week 24. Results: In total, 454 TEs were extracted (159 adalimumab; 193 etanercept; 19 infliximab; 83 ustekinumab) from 326 patients. At week 24, in 3%, 15% and 59% of TEs, respectively, PASI 100, PASI 90 and PASI ≤ 5 was reached. In TEs without a PASI 100 or PASI 90 response, PASI ≤ 5 was still achieved in 58% and 52%, respectively. Baseline PASI ≥ 10 was a strong predictor for achieving PASI 90; baseline PASI < 10 and a lower baseline body mass index (BMI) were significant predictors for PASI ≤ 5 at week 24. Conclusions: A limited number of patients achieved PASI 100 or PASI 90 at 24 weeks of biological treatment. Including an absolute PASI score in the assessment of psoriasis severity is important. Baseline BMI was an important, modifiable predictor for a high response.

Original languageEnglish
Pages (from-to)786-793
Number of pages8
JournalBritish Journal of Dermatology
Volume176
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Cite this

Zweegers, J., Roosenboom, B., van de Kerkhof, P. C. M., van den Reek, J. M. P. A., Otero, M. E., Atalay, S., ... de Jong, E. M. G. J. (2017). Frequency and predictors of a high clinical response in patients with psoriasis on biological therapy in daily practice: results from the prospective, multicenter BioCAPTURE cohort. British Journal of Dermatology, 176(3), 786-793. https://doi.org/10.1111/bjd.14888