From proteomics toward systems biology: Integration of different types of proteomics data into network models

Sangchul Rho, Sungyong You, Yongsoo Kim, Daehee Hwang*

*Corresponding author for this work

Research output: Contribution to journalShort surveyAcademicpeer-review

Abstract

Living organisms are comprised of various systems at different levels, i.e., organs, tissues, and cells. Each system carries out its diverse functions in response to environmental and genetic perturbations, by utilizing biological networks, in which nodal components, such as, DNA, mRNAs, proteins, and metabolites, closely interact with each other. Systems biology investigates such systems by producing comprehensive global data that represent different levels of biological information, i.e., at the DNA, mRNA, protein, or metabolite levels, and by integrating this data into network models that generate coherent hypotheses for given biological situations. This review presents a systems biology framework, called the 'Integrative Proteomics Data Analysis Pipeline' (IPDAP), which generates mechanistic hypotheses from network models reconstructed by integrating diverse types of proteomic data generated by mass spectrometry-based proteomic analyses. The devised framework includes a serial set of computational and network analysis tools. Here, we demonstrate its functionalities by applying these tools to several conceptual examples.

Original languageEnglish
Pages (from-to)184-193
Number of pages10
JournalJournal of Biochemistry and Molecular Biology
Volume41
Issue number3
Publication statusPublished - 1 Mar 2008

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