From stem cells to lymphocytes: biology and transplantation

H L Aguila, K Akashi, J Domen, K L Gandy, E Lagasse, R E Mebius, S J Morrison, J Shizuru, S Strober, N Uchida, D E Wright, I L Weissman

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

LanguageEnglish
Pages13-40
Number of pages28
JournalImmunological Reviews
Volume157
Publication statusPublished - Jun 1997

Cite this

Aguila, H. L., Akashi, K., Domen, J., Gandy, K. L., Lagasse, E., Mebius, R. E., ... Weissman, I. L. (1997). From stem cells to lymphocytes: biology and transplantation. Immunological Reviews, 157, 13-40.
Aguila, H L ; Akashi, K ; Domen, J ; Gandy, K L ; Lagasse, E ; Mebius, R E ; Morrison, S J ; Shizuru, J ; Strober, S ; Uchida, N ; Wright, D E ; Weissman, I L. / From stem cells to lymphocytes : biology and transplantation. In: Immunological Reviews. 1997 ; Vol. 157. pp. 13-40.
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Aguila, HL, Akashi, K, Domen, J, Gandy, KL, Lagasse, E, Mebius, RE, Morrison, SJ, Shizuru, J, Strober, S, Uchida, N, Wright, DE & Weissman, IL 1997, 'From stem cells to lymphocytes: biology and transplantation', Immunological Reviews, vol. 157, pp. 13-40.

From stem cells to lymphocytes : biology and transplantation. / Aguila, H L; Akashi, K; Domen, J; Gandy, K L; Lagasse, E; Mebius, R E; Morrison, S J; Shizuru, J; Strober, S; Uchida, N; Wright, D E; Weissman, I L.

In: Immunological Reviews, Vol. 157, 06.1997, p. 13-40.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - From stem cells to lymphocytes

T2 - Immunological Reviews

AU - Aguila, H L

AU - Akashi, K

AU - Domen, J

AU - Gandy, K L

AU - Lagasse, E

AU - Mebius, R E

AU - Morrison, S J

AU - Shizuru, J

AU - Strober, S

AU - Uchida, N

AU - Wright, D E

AU - Weissman, I L

PY - 1997/6

Y1 - 1997/6

N2 - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

AB - We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cells. This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T-cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl-2 in regulating homeostasis in the hematopoietic system is discussed.

KW - Animals

KW - Hematopoietic Stem Cell Transplantation/history

KW - Hematopoietic Stem Cells/immunology

KW - History, 20th Century

KW - Humans

KW - Transplantation Immunology

M3 - Review article

VL - 157

SP - 13

EP - 40

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

ER -

Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE et al. From stem cells to lymphocytes: biology and transplantation. Immunological Reviews. 1997 Jun;157:13-40.