Fronto-parietal coupling of brain rhythms in mild cognitive impairment: a multicentric EEG study

Claudio Babiloni, Raffaele Ferri, Giuliano Binetti, Andrea Cassarino, Gloria Dal Forno, Matilde Ercolani, Florinda Ferreri, Giovanni B Frisoni, Bartolo Lanuzza, Carlo Miniussi, Flavio Nobili, Guido Rodriguez, Francesco Rundo, Cornelis J Stam, Toshimitsu Musha, Fabrizio Vecchio, Paolo M Rossini

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Electroencephalographic (EEG) data were recorded in 69 normal elderly (Nold), 88 mild cognitive impairment (MCI), and 109 mild Alzheimer's disease (AD) subjects at rest condition, to test whether the fronto-parietal coupling of EEG rhythms is in line with the hypothesis that MCI can be considered as a pre-clinical stage of the disease at group level. Functional coupling was estimated by synchronization likelihood of Laplacian-transformed EEG data at electrode pairs, which accounts for linear and non-linear components of that coupling. Cortical rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), beta 2 (20-30Hz), and gamma (30-40Hz). Compared to the Nold subjects, the AD patients presented a marked reduction of the synchronization likelihood (delta to gamma) at both fronto-parietal and inter-hemispherical (delta to beta 2) electrodes. As a main result, alpha 1 synchronization likelihood progressively decreased across Nold, MCI, and mild AD subjects at midline (Fz-Pz) and right (F4-P4) fronto-parietal electrodes. The same was true for the delta synchronization likelihood at right fronto-parietal electrodes (F4-P4). For these EEG bands, the synchronization likelihood correlated with global cognitive status as measured by the Mini Mental State Evaluation. The present results suggest that at group level, fronto-parietal coupling of the delta and alpha rhythms progressively becomes abnormal though MCI and mild AD. Future longitudinal research should evaluate whether the present EEG approach is able to predict the cognitive decline in individual MCI subjects.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalBrain Research Bulletin
Volume69
Issue number1
DOIs
Publication statusPublished - 15 Mar 2006

Cite this

Babiloni, C., Ferri, R., Binetti, G., Cassarino, A., Dal Forno, G., Ercolani, M., ... Rossini, P. M. (2006). Fronto-parietal coupling of brain rhythms in mild cognitive impairment: a multicentric EEG study. Brain Research Bulletin, 69(1), 63-73. https://doi.org/10.1016/j.brainresbull.2005.10.013