Fronto-striatal network activation leads to less fatigue in multiple sclerosis

Ekaterina Dobryakova, Hanneke E Hulst, Angela Spirou, Nancy D Chiaravalloti, Helen M Genova, Glenn R Wylie, John DeLuca

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: The fronto-striatal network has been implicated in both fatigue, a common multiple sclerosis (MS) symptom, and goal attainment, which has been shown to reduce fatigue in healthy individuals.

OBJECTIVES: To investigate whether stimulation of the fronto-striatal network through goal attainment (potential monetary gain) leads to fatigue reduction in MS and healthy control (HC) participants.

METHODS: In all, 14 healthy and 19 MS participants performed a gambling task during functional magnetic resonance imaging (fMRI). Participants were presented with an opportunity to receive monetary reward during the outcome condition of the task but not during the no outcome condition. Self-reported fatigue measures were obtained after each condition and outside of the scanner. Structural alterations were also examined.

RESULTS: A significant decrease in fatigue was observed after the outcome condition compared to the no outcome condition in both groups. Significantly greater activation was observed in the ventral striatum in association with the outcome condition compared to the no outcome condition in both groups. Ventromedial prefrontal cortex showed significantly greater activation during the no outcome condition compared to the outcome condition with greater difference between conditions in the HC group.

CONCLUSION: This is the first functional neuroimaging study showing that stimulation of the fronto-striatal network through goal attainment leads to decreased on-task fatigue in MS and healthy participants.

Original languageEnglish
Pages (from-to)1174-1182
Number of pages9
JournalMultiple Sclerosis
Volume24
Issue number9
Early online date1 Jun 2017
DOIs
Publication statusPublished - 1 Aug 2018

Cite this

Dobryakova, E., Hulst, H. E., Spirou, A., Chiaravalloti, N. D., Genova, H. M., Wylie, G. R., & DeLuca, J. (2018). Fronto-striatal network activation leads to less fatigue in multiple sclerosis. Multiple Sclerosis, 24(9), 1174-1182. https://doi.org/10.1177/1352458517717087
Dobryakova, Ekaterina ; Hulst, Hanneke E ; Spirou, Angela ; Chiaravalloti, Nancy D ; Genova, Helen M ; Wylie, Glenn R ; DeLuca, John. / Fronto-striatal network activation leads to less fatigue in multiple sclerosis. In: Multiple Sclerosis. 2018 ; Vol. 24, No. 9. pp. 1174-1182.
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abstract = "BACKGROUND: The fronto-striatal network has been implicated in both fatigue, a common multiple sclerosis (MS) symptom, and goal attainment, which has been shown to reduce fatigue in healthy individuals.OBJECTIVES: To investigate whether stimulation of the fronto-striatal network through goal attainment (potential monetary gain) leads to fatigue reduction in MS and healthy control (HC) participants.METHODS: In all, 14 healthy and 19 MS participants performed a gambling task during functional magnetic resonance imaging (fMRI). Participants were presented with an opportunity to receive monetary reward during the outcome condition of the task but not during the no outcome condition. Self-reported fatigue measures were obtained after each condition and outside of the scanner. Structural alterations were also examined.RESULTS: A significant decrease in fatigue was observed after the outcome condition compared to the no outcome condition in both groups. Significantly greater activation was observed in the ventral striatum in association with the outcome condition compared to the no outcome condition in both groups. Ventromedial prefrontal cortex showed significantly greater activation during the no outcome condition compared to the outcome condition with greater difference between conditions in the HC group.CONCLUSION: This is the first functional neuroimaging study showing that stimulation of the fronto-striatal network through goal attainment leads to decreased on-task fatigue in MS and healthy participants.",
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Dobryakova, E, Hulst, HE, Spirou, A, Chiaravalloti, ND, Genova, HM, Wylie, GR & DeLuca, J 2018, 'Fronto-striatal network activation leads to less fatigue in multiple sclerosis' Multiple Sclerosis, vol. 24, no. 9, pp. 1174-1182. https://doi.org/10.1177/1352458517717087

Fronto-striatal network activation leads to less fatigue in multiple sclerosis. / Dobryakova, Ekaterina; Hulst, Hanneke E; Spirou, Angela; Chiaravalloti, Nancy D; Genova, Helen M; Wylie, Glenn R; DeLuca, John.

In: Multiple Sclerosis, Vol. 24, No. 9, 01.08.2018, p. 1174-1182.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Fronto-striatal network activation leads to less fatigue in multiple sclerosis

AU - Dobryakova, Ekaterina

AU - Hulst, Hanneke E

AU - Spirou, Angela

AU - Chiaravalloti, Nancy D

AU - Genova, Helen M

AU - Wylie, Glenn R

AU - DeLuca, John

PY - 2018/8/1

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N2 - BACKGROUND: The fronto-striatal network has been implicated in both fatigue, a common multiple sclerosis (MS) symptom, and goal attainment, which has been shown to reduce fatigue in healthy individuals.OBJECTIVES: To investigate whether stimulation of the fronto-striatal network through goal attainment (potential monetary gain) leads to fatigue reduction in MS and healthy control (HC) participants.METHODS: In all, 14 healthy and 19 MS participants performed a gambling task during functional magnetic resonance imaging (fMRI). Participants were presented with an opportunity to receive monetary reward during the outcome condition of the task but not during the no outcome condition. Self-reported fatigue measures were obtained after each condition and outside of the scanner. Structural alterations were also examined.RESULTS: A significant decrease in fatigue was observed after the outcome condition compared to the no outcome condition in both groups. Significantly greater activation was observed in the ventral striatum in association with the outcome condition compared to the no outcome condition in both groups. Ventromedial prefrontal cortex showed significantly greater activation during the no outcome condition compared to the outcome condition with greater difference between conditions in the HC group.CONCLUSION: This is the first functional neuroimaging study showing that stimulation of the fronto-striatal network through goal attainment leads to decreased on-task fatigue in MS and healthy participants.

AB - BACKGROUND: The fronto-striatal network has been implicated in both fatigue, a common multiple sclerosis (MS) symptom, and goal attainment, which has been shown to reduce fatigue in healthy individuals.OBJECTIVES: To investigate whether stimulation of the fronto-striatal network through goal attainment (potential monetary gain) leads to fatigue reduction in MS and healthy control (HC) participants.METHODS: In all, 14 healthy and 19 MS participants performed a gambling task during functional magnetic resonance imaging (fMRI). Participants were presented with an opportunity to receive monetary reward during the outcome condition of the task but not during the no outcome condition. Self-reported fatigue measures were obtained after each condition and outside of the scanner. Structural alterations were also examined.RESULTS: A significant decrease in fatigue was observed after the outcome condition compared to the no outcome condition in both groups. Significantly greater activation was observed in the ventral striatum in association with the outcome condition compared to the no outcome condition in both groups. Ventromedial prefrontal cortex showed significantly greater activation during the no outcome condition compared to the outcome condition with greater difference between conditions in the HC group.CONCLUSION: This is the first functional neuroimaging study showing that stimulation of the fronto-striatal network through goal attainment leads to decreased on-task fatigue in MS and healthy participants.

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Dobryakova E, Hulst HE, Spirou A, Chiaravalloti ND, Genova HM, Wylie GR et al. Fronto-striatal network activation leads to less fatigue in multiple sclerosis. Multiple Sclerosis. 2018 Aug 1;24(9):1174-1182. https://doi.org/10.1177/1352458517717087