Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Resting-state functional connectivity patterns are highly stable over time within subjects. This suggests that such 'functional fingerprints' may have strong genetic component. We investigated whether the functional (FC) or effective (EC) connectivity patterns of one monozygotic twin could be used to identify the co-twin among a larger sample and determined the overlap in functional fingerprints within monozygotic (MZ) twin pairs using resting state magnetoencephalography (MEG). We included 32 cognitively normal MZ twin pairs from the Netherlands Twin Register who participate in the EMIF-AD preclinAD study (average age 68 years). Combining EC information across multiple frequency bands we obtained an identification rate over 75%. Since MZ twin pairs are genetically identical these results suggest a high genetic contribution to MEG-based EC patterns, leading to large similarities in brain connectivity patterns between two individuals even after 60 years of life or more.

Original languageEnglish
Article number9685
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

@article{365fd05e07c4447ea0f1745e258ed3ff,
title = "Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs",
abstract = "Resting-state functional connectivity patterns are highly stable over time within subjects. This suggests that such 'functional fingerprints' may have strong genetic component. We investigated whether the functional (FC) or effective (EC) connectivity patterns of one monozygotic twin could be used to identify the co-twin among a larger sample and determined the overlap in functional fingerprints within monozygotic (MZ) twin pairs using resting state magnetoencephalography (MEG). We included 32 cognitively normal MZ twin pairs from the Netherlands Twin Register who participate in the EMIF-AD preclinAD study (average age 68 years). Combining EC information across multiple frequency bands we obtained an identification rate over 75{\%}. Since MZ twin pairs are genetically identical these results suggest a high genetic contribution to MEG-based EC patterns, leading to large similarities in brain connectivity patterns between two individuals even after 60 years of life or more.",
author = "M. Demuru and Gouw, {A. A.} and A. Hillebrand and Stam, {C. J.} and {Van Dijk}, {B. W.} and P. Scheltens and Tijms, {B. M.} and E. Konijnenberg and {Ten Kate}, M. and {Den Braber}, A. and Smit, {D. J.A.} and D.I. Boomsma and Visser, {P. J.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-10235-y",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
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TY - JOUR

T1 - Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs

AU - Demuru, M.

AU - Gouw, A. A.

AU - Hillebrand, A.

AU - Stam, C. J.

AU - Van Dijk, B. W.

AU - Scheltens, P.

AU - Tijms, B. M.

AU - Konijnenberg, E.

AU - Ten Kate, M.

AU - Den Braber, A.

AU - Smit, D. J.A.

AU - Boomsma, D.I.

AU - Visser, P. J.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Resting-state functional connectivity patterns are highly stable over time within subjects. This suggests that such 'functional fingerprints' may have strong genetic component. We investigated whether the functional (FC) or effective (EC) connectivity patterns of one monozygotic twin could be used to identify the co-twin among a larger sample and determined the overlap in functional fingerprints within monozygotic (MZ) twin pairs using resting state magnetoencephalography (MEG). We included 32 cognitively normal MZ twin pairs from the Netherlands Twin Register who participate in the EMIF-AD preclinAD study (average age 68 years). Combining EC information across multiple frequency bands we obtained an identification rate over 75%. Since MZ twin pairs are genetically identical these results suggest a high genetic contribution to MEG-based EC patterns, leading to large similarities in brain connectivity patterns between two individuals even after 60 years of life or more.

AB - Resting-state functional connectivity patterns are highly stable over time within subjects. This suggests that such 'functional fingerprints' may have strong genetic component. We investigated whether the functional (FC) or effective (EC) connectivity patterns of one monozygotic twin could be used to identify the co-twin among a larger sample and determined the overlap in functional fingerprints within monozygotic (MZ) twin pairs using resting state magnetoencephalography (MEG). We included 32 cognitively normal MZ twin pairs from the Netherlands Twin Register who participate in the EMIF-AD preclinAD study (average age 68 years). Combining EC information across multiple frequency bands we obtained an identification rate over 75%. Since MZ twin pairs are genetically identical these results suggest a high genetic contribution to MEG-based EC patterns, leading to large similarities in brain connectivity patterns between two individuals even after 60 years of life or more.

UR - http://www.scopus.com/inward/record.url?scp=85028511897&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-10235-y

DO - 10.1038/s41598-017-10235-y

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 9685

ER -