Further Evidence of a Cohort Effect in Bipolar Disorder: More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs

Robert M Post, Ralph Kupka, Paul E Keck, Susan L McElroy, Lori L Altshuler, Mark A Frye, Michael Rowe, Heinz Grunze, Trisha Suppes, Gabriele S Leverich, Willem A Nolen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: Given that a cohort effect is rarely mentioned as one of the possible contributors to the increased incidence of childhood-onset bipolar disorder in the United States, we reexamined evidence for the phenomenon within our outpatient Bipolar Collaborative Network.

METHODS: 968 outpatients (mean age, 41 years) with DSM bipolar disorder from 1995 to 2002 from 4 sites in the United States and 3 in the Netherlands and Germany (abbreviated as Europe) gave informed consent and provided detailed demographic, illness, and family history information on a patient questionnaire. Family history of bipolar disorder, depression, suicide attempt, alcohol abuse, substance abuse, and "other" illness was collected for each parent and the 4 grandparents. Age at onset and family history of illness burden were then assessed as a function of the age of the patient at network entry.

RESULTS: Data for patients aged 35 years or older (n = 613) were included in the first analysis. Compared to older patients, those who were younger when they entered the network had an earlier age at onset of their bipolar disorder (r = 0.33, P < .001). Similarly, the youngest patients at entry (representing the most recent cohorts) had parents and grandparents with more psychiatric illness than patients born in earlier cohorts (n = 968).

CONCLUSIONS: These preliminary data, taken with the substantial literature, suggest a cohort effect for earlier age at onset of bipolar disorder and greater burden of psychiatric disorders in 2 generations of direct progenitors of our patients. The resulting likely increase in severity of bipolar illness in future generations based on this earlier age at onset and increased familial loading, particularly in the United States, deserves focused clinical and public health attention and attempts at amelioration.

Original languageEnglish
Pages (from-to)1043-1049
Number of pages7
JournalJournal of Clinical Psychiatry
Volume77
Issue number8
DOIs
Publication statusPublished - Aug 2016

Cite this

Post, Robert M ; Kupka, Ralph ; Keck, Paul E ; McElroy, Susan L ; Altshuler, Lori L ; Frye, Mark A ; Rowe, Michael ; Grunze, Heinz ; Suppes, Trisha ; Leverich, Gabriele S ; Nolen, Willem A. / Further Evidence of a Cohort Effect in Bipolar Disorder : More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs. In: Journal of Clinical Psychiatry. 2016 ; Vol. 77, No. 8. pp. 1043-1049.
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abstract = "OBJECTIVE: Given that a cohort effect is rarely mentioned as one of the possible contributors to the increased incidence of childhood-onset bipolar disorder in the United States, we reexamined evidence for the phenomenon within our outpatient Bipolar Collaborative Network.METHODS: 968 outpatients (mean age, 41 years) with DSM bipolar disorder from 1995 to 2002 from 4 sites in the United States and 3 in the Netherlands and Germany (abbreviated as Europe) gave informed consent and provided detailed demographic, illness, and family history information on a patient questionnaire. Family history of bipolar disorder, depression, suicide attempt, alcohol abuse, substance abuse, and {"}other{"} illness was collected for each parent and the 4 grandparents. Age at onset and family history of illness burden were then assessed as a function of the age of the patient at network entry.RESULTS: Data for patients aged 35 years or older (n = 613) were included in the first analysis. Compared to older patients, those who were younger when they entered the network had an earlier age at onset of their bipolar disorder (r = 0.33, P < .001). Similarly, the youngest patients at entry (representing the most recent cohorts) had parents and grandparents with more psychiatric illness than patients born in earlier cohorts (n = 968).CONCLUSIONS: These preliminary data, taken with the substantial literature, suggest a cohort effect for earlier age at onset of bipolar disorder and greater burden of psychiatric disorders in 2 generations of direct progenitors of our patients. The resulting likely increase in severity of bipolar illness in future generations based on this earlier age at onset and increased familial loading, particularly in the United States, deserves focused clinical and public health attention and attempts at amelioration.",
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Post, RM, Kupka, R, Keck, PE, McElroy, SL, Altshuler, LL, Frye, MA, Rowe, M, Grunze, H, Suppes, T, Leverich, GS & Nolen, WA 2016, 'Further Evidence of a Cohort Effect in Bipolar Disorder: More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs' Journal of Clinical Psychiatry, vol. 77, no. 8, pp. 1043-1049. https://doi.org/10.4088/JCP.15m10121

Further Evidence of a Cohort Effect in Bipolar Disorder : More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs. / Post, Robert M; Kupka, Ralph; Keck, Paul E; McElroy, Susan L; Altshuler, Lori L; Frye, Mark A; Rowe, Michael; Grunze, Heinz; Suppes, Trisha; Leverich, Gabriele S; Nolen, Willem A.

In: Journal of Clinical Psychiatry, Vol. 77, No. 8, 08.2016, p. 1043-1049.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Further Evidence of a Cohort Effect in Bipolar Disorder

T2 - More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs

AU - Post, Robert M

AU - Kupka, Ralph

AU - Keck, Paul E

AU - McElroy, Susan L

AU - Altshuler, Lori L

AU - Frye, Mark A

AU - Rowe, Michael

AU - Grunze, Heinz

AU - Suppes, Trisha

AU - Leverich, Gabriele S

AU - Nolen, Willem A

N1 - © Copyright 2016 Physicians Postgraduate Press, Inc.

PY - 2016/8

Y1 - 2016/8

N2 - OBJECTIVE: Given that a cohort effect is rarely mentioned as one of the possible contributors to the increased incidence of childhood-onset bipolar disorder in the United States, we reexamined evidence for the phenomenon within our outpatient Bipolar Collaborative Network.METHODS: 968 outpatients (mean age, 41 years) with DSM bipolar disorder from 1995 to 2002 from 4 sites in the United States and 3 in the Netherlands and Germany (abbreviated as Europe) gave informed consent and provided detailed demographic, illness, and family history information on a patient questionnaire. Family history of bipolar disorder, depression, suicide attempt, alcohol abuse, substance abuse, and "other" illness was collected for each parent and the 4 grandparents. Age at onset and family history of illness burden were then assessed as a function of the age of the patient at network entry.RESULTS: Data for patients aged 35 years or older (n = 613) were included in the first analysis. Compared to older patients, those who were younger when they entered the network had an earlier age at onset of their bipolar disorder (r = 0.33, P < .001). Similarly, the youngest patients at entry (representing the most recent cohorts) had parents and grandparents with more psychiatric illness than patients born in earlier cohorts (n = 968).CONCLUSIONS: These preliminary data, taken with the substantial literature, suggest a cohort effect for earlier age at onset of bipolar disorder and greater burden of psychiatric disorders in 2 generations of direct progenitors of our patients. The resulting likely increase in severity of bipolar illness in future generations based on this earlier age at onset and increased familial loading, particularly in the United States, deserves focused clinical and public health attention and attempts at amelioration.

AB - OBJECTIVE: Given that a cohort effect is rarely mentioned as one of the possible contributors to the increased incidence of childhood-onset bipolar disorder in the United States, we reexamined evidence for the phenomenon within our outpatient Bipolar Collaborative Network.METHODS: 968 outpatients (mean age, 41 years) with DSM bipolar disorder from 1995 to 2002 from 4 sites in the United States and 3 in the Netherlands and Germany (abbreviated as Europe) gave informed consent and provided detailed demographic, illness, and family history information on a patient questionnaire. Family history of bipolar disorder, depression, suicide attempt, alcohol abuse, substance abuse, and "other" illness was collected for each parent and the 4 grandparents. Age at onset and family history of illness burden were then assessed as a function of the age of the patient at network entry.RESULTS: Data for patients aged 35 years or older (n = 613) were included in the first analysis. Compared to older patients, those who were younger when they entered the network had an earlier age at onset of their bipolar disorder (r = 0.33, P < .001). Similarly, the youngest patients at entry (representing the most recent cohorts) had parents and grandparents with more psychiatric illness than patients born in earlier cohorts (n = 968).CONCLUSIONS: These preliminary data, taken with the substantial literature, suggest a cohort effect for earlier age at onset of bipolar disorder and greater burden of psychiatric disorders in 2 generations of direct progenitors of our patients. The resulting likely increase in severity of bipolar illness in future generations based on this earlier age at onset and increased familial loading, particularly in the United States, deserves focused clinical and public health attention and attempts at amelioration.

KW - Bipolar Disorder

U2 - 10.4088/JCP.15m10121

DO - 10.4088/JCP.15m10121

M3 - Article

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JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

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ER -