Further validation of the THINC-it tool and extension of the normative data set in a study of n = 10.019 typical controls

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Introduction: We report further validation and normative data for the THINC-Integrated Tool (THINC-it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neurological diseases. THINC-it comprises four objective computerised cognitive tests based on traditional psychological paradigms and a version of the Perceived Deficits Questionnaire assessment. Methods: Sample size of n = 10.019 typical control study participants were tested on one to two occasions to further validate the reliability of THINC-it. Temporal reliability was assessed across 120–180 days. Results: Test-retest reliability correlations varied between r = 0.50 and 0.72 for the component measures and r = 0.75 (95% confidence intervals 0.74, 0.76) for the THINC-it composite score. Normative data categorised by Age, Sex and Years of Education were calculated and the effect on task performance was reported. Discussion: Our analysis confirms previously reported levels of reliability and validates previously reported normative data values.
Original languageEnglish
Article numbere1922
JournalInternational Journal of Methods in Psychiatric Research
Issue number4
Early online date2022
Publication statusPublished - Dec 2022
Externally publishedYes

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