Gait in elderly with cerebral small vessel disease

Karlijn F de Laat, Anouk G W van Norden, Rob A R Gons, Lucas J B van Oudheusden, Inge W M van Uden, Bastiaan R Bloem, Marcel P Zwiers, Frank-Erik de Leeuw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND AND PURPOSE: Gait disorders are common in the elderly and are related to loss of functional independence and death. White matter lesions (WMLs) may be related, but only a minority of individuals with WMLs has gait disorders. Probably other factors are involved, including location and the independent effect of frequently coinciding lacunar infarcts, the other aspect of cerebral small vessel disease. The aim of our study was to investigate the effect of both the severity and location of both WMLs and lacunar infarcts on gait.

METHODS: Four hundred thirty-one independently living, nondemented elderly aged between 50 and 85 years with cerebral small vessel disease were included in this analysis and underwent MRI scanning. The number and location of lacunar infarcts were rated and WML volume was assessed by manual segmentation with automated delineating of different regions. Gait was assessed quantitatively with an electronic walkway as well as the semiquantitatively Tinetti and Timed-Up-and-Go test.

RESULTS: WMLs and lacunar infarcts were both independently associated with most gait parameters with stride length as the most sensitive parameter related to WMLs. WMLs in the sublobar (basal ganglia/internal capsule) and limbic areas and lacunar infarcts in the frontal lobe and thalamus were related to a lower velocity.

CONCLUSIONS: Cerebral small vessel disease is related to gait disturbances. Because small vessel disease may, in part, be preventable, it should be regarded as a potentially important target for postponing gait impairment.

Original languageEnglish
Pages (from-to)1652-8
Number of pages7
JournalStroke
Volume41
Issue number8
DOIs
Publication statusPublished - Aug 2010

Cite this

de Laat, K. F., van Norden, A. G. W., Gons, R. A. R., van Oudheusden, L. J. B., van Uden, I. W. M., Bloem, B. R., ... de Leeuw, F-E. (2010). Gait in elderly with cerebral small vessel disease. Stroke, 41(8), 1652-8. https://doi.org/10.1161/STROKEAHA.110.583229
de Laat, Karlijn F ; van Norden, Anouk G W ; Gons, Rob A R ; van Oudheusden, Lucas J B ; van Uden, Inge W M ; Bloem, Bastiaan R ; Zwiers, Marcel P ; de Leeuw, Frank-Erik. / Gait in elderly with cerebral small vessel disease. In: Stroke. 2010 ; Vol. 41, No. 8. pp. 1652-8.
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abstract = "BACKGROUND AND PURPOSE: Gait disorders are common in the elderly and are related to loss of functional independence and death. White matter lesions (WMLs) may be related, but only a minority of individuals with WMLs has gait disorders. Probably other factors are involved, including location and the independent effect of frequently coinciding lacunar infarcts, the other aspect of cerebral small vessel disease. The aim of our study was to investigate the effect of both the severity and location of both WMLs and lacunar infarcts on gait.METHODS: Four hundred thirty-one independently living, nondemented elderly aged between 50 and 85 years with cerebral small vessel disease were included in this analysis and underwent MRI scanning. The number and location of lacunar infarcts were rated and WML volume was assessed by manual segmentation with automated delineating of different regions. Gait was assessed quantitatively with an electronic walkway as well as the semiquantitatively Tinetti and Timed-Up-and-Go test.RESULTS: WMLs and lacunar infarcts were both independently associated with most gait parameters with stride length as the most sensitive parameter related to WMLs. WMLs in the sublobar (basal ganglia/internal capsule) and limbic areas and lacunar infarcts in the frontal lobe and thalamus were related to a lower velocity.CONCLUSIONS: Cerebral small vessel disease is related to gait disturbances. Because small vessel disease may, in part, be preventable, it should be regarded as a potentially important target for postponing gait impairment.",
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de Laat, KF, van Norden, AGW, Gons, RAR, van Oudheusden, LJB, van Uden, IWM, Bloem, BR, Zwiers, MP & de Leeuw, F-E 2010, 'Gait in elderly with cerebral small vessel disease' Stroke, vol. 41, no. 8, pp. 1652-8. https://doi.org/10.1161/STROKEAHA.110.583229

Gait in elderly with cerebral small vessel disease. / de Laat, Karlijn F; van Norden, Anouk G W; Gons, Rob A R; van Oudheusden, Lucas J B; van Uden, Inge W M; Bloem, Bastiaan R; Zwiers, Marcel P; de Leeuw, Frank-Erik.

In: Stroke, Vol. 41, No. 8, 08.2010, p. 1652-8.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Gait in elderly with cerebral small vessel disease

AU - de Laat, Karlijn F

AU - van Norden, Anouk G W

AU - Gons, Rob A R

AU - van Oudheusden, Lucas J B

AU - van Uden, Inge W M

AU - Bloem, Bastiaan R

AU - Zwiers, Marcel P

AU - de Leeuw, Frank-Erik

PY - 2010/8

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N2 - BACKGROUND AND PURPOSE: Gait disorders are common in the elderly and are related to loss of functional independence and death. White matter lesions (WMLs) may be related, but only a minority of individuals with WMLs has gait disorders. Probably other factors are involved, including location and the independent effect of frequently coinciding lacunar infarcts, the other aspect of cerebral small vessel disease. The aim of our study was to investigate the effect of both the severity and location of both WMLs and lacunar infarcts on gait.METHODS: Four hundred thirty-one independently living, nondemented elderly aged between 50 and 85 years with cerebral small vessel disease were included in this analysis and underwent MRI scanning. The number and location of lacunar infarcts were rated and WML volume was assessed by manual segmentation with automated delineating of different regions. Gait was assessed quantitatively with an electronic walkway as well as the semiquantitatively Tinetti and Timed-Up-and-Go test.RESULTS: WMLs and lacunar infarcts were both independently associated with most gait parameters with stride length as the most sensitive parameter related to WMLs. WMLs in the sublobar (basal ganglia/internal capsule) and limbic areas and lacunar infarcts in the frontal lobe and thalamus were related to a lower velocity.CONCLUSIONS: Cerebral small vessel disease is related to gait disturbances. Because small vessel disease may, in part, be preventable, it should be regarded as a potentially important target for postponing gait impairment.

AB - BACKGROUND AND PURPOSE: Gait disorders are common in the elderly and are related to loss of functional independence and death. White matter lesions (WMLs) may be related, but only a minority of individuals with WMLs has gait disorders. Probably other factors are involved, including location and the independent effect of frequently coinciding lacunar infarcts, the other aspect of cerebral small vessel disease. The aim of our study was to investigate the effect of both the severity and location of both WMLs and lacunar infarcts on gait.METHODS: Four hundred thirty-one independently living, nondemented elderly aged between 50 and 85 years with cerebral small vessel disease were included in this analysis and underwent MRI scanning. The number and location of lacunar infarcts were rated and WML volume was assessed by manual segmentation with automated delineating of different regions. Gait was assessed quantitatively with an electronic walkway as well as the semiquantitatively Tinetti and Timed-Up-and-Go test.RESULTS: WMLs and lacunar infarcts were both independently associated with most gait parameters with stride length as the most sensitive parameter related to WMLs. WMLs in the sublobar (basal ganglia/internal capsule) and limbic areas and lacunar infarcts in the frontal lobe and thalamus were related to a lower velocity.CONCLUSIONS: Cerebral small vessel disease is related to gait disturbances. Because small vessel disease may, in part, be preventable, it should be regarded as a potentially important target for postponing gait impairment.

KW - Age Factors

KW - Aged

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KW - Brain/pathology

KW - Cerebral Infarction/pathology

KW - Cerebrovascular Disorders/pathology

KW - Cohort Studies

KW - Female

KW - Gait/physiology

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Nerve Fibers, Myelinated/pathology

KW - Patient Selection

KW - Prospective Studies

KW - Severity of Illness Index

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DO - 10.1161/STROKEAHA.110.583229

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SN - 0039-2499

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de Laat KF, van Norden AGW, Gons RAR, van Oudheusden LJB, van Uden IWM, Bloem BR et al. Gait in elderly with cerebral small vessel disease. Stroke. 2010 Aug;41(8):1652-8. https://doi.org/10.1161/STROKEAHA.110.583229