Gamma-glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus

Diewertje Sluik*, Joline W.J. Beulens, Cornelia Weikert, Susan Van Dieren, Annemieke M.W. Spijkerman, Daphne L. Van der A, Andreas Fritsche, Hans Georg Joost, Heiner Boeing, Ute Nöthlings

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Increased plasma activity of gamma-glutamyltransferase (GGT) is associated with cardiovascular diseases (CVD) and mortality in the general population. We investigated the association between GGT, CVD and mortality in individuals with diabetes mellitus. Methods: Data used were from 1280 participants, aged 35-70years, with a confirmed diagnosis of diabetes mellitus in the European Prospective Investigation into Cancer and Nutrition in Potsdam (Germany), Bilthoven and Utrecht (the Netherlands). Multivariate hazard ratios (HR) and 95% confidence intervals (CI) for CVD (non-fatal and fatal events) and overall mortality were estimated using sex-specific quartiles of GGT. Results: After 8.2years follow-up, 108 incident CVD cases and 84 deaths were observed. Participants with high GGT activity had an increased mortality risk: HR in the highest quartile was 3.96 (95% CI 1.74, 9.00). This association was in particular present in former and current smokers, younger persons and those with a higher waist-height ratio and alcohol consumption. No associations were observed for non-fatal CVD and non-fatal and fatal CVD events combined. Conclusions: Higher GGT plasma activity is associated with increased all-cause mortality in individuals with diabetes.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalDiabetes/Metabolism Research and Reviews
Issue number3
Publication statusPublished - 1 Mar 2012

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