Generating diagnostic profiles of cognitive decline and dementia using magnetoencephalography

Elliz P. Scheijbeler*, Deborah N. Schoonhoven, Marjolein M. A. Engels, Philip Scheltens, Cornelis J. Stam, Alida A. Gouw, Arjan Hillebrand

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Accurate identification of the underlying cause(s) of cognitive decline and dementia is challenging due to significant symptomatic overlap between subtypes. This study presents a multi-class classification framework for subjects with subjective cognitive decline, mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, fronto-temporal dementia and cognitive decline due to psychiatric illness, trained on source-localized resting-state magnetoencephalography data. Diagnostic profiles, describing probability estimates for each of the 6 diagnoses, were assigned to individual subjects. A balanced accuracy rate of 41% and multi-class area under the curve value of 0.75 were obtained for 6-class classification. Classification primarily depended on posterior relative delta, theta and beta power and amplitude-based functional connectivity in the beta and gamma frequency band. Dementia with Lewy bodies (sensitivity: 100%, precision: 20%) and Alzheimer's disease subjects (sensitivity: 51%, precision: 90%) could be classified most accurately. Fronto-temporal dementia subjects (sensitivity: 11%, precision: 3%) were most frequently misclassified. Magnetoencephalography biomarkers hold promise to increase diagnostic accuracy in a noninvasive manner. Diagnostic profiles could provide an intuitive tool to clinicians and may facilitate implementation of the classifier in the memory clinic.
Original languageEnglish
Pages (from-to)82-94
Number of pages13
JournalNeurobiology of Aging
Early online date2021
Publication statusPublished - Mar 2022

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