Genetic obesity: New diagnostic options

Tamar I. De Vries, Suzanne I.M. Alsters, Lotte Kleinendorst, Gijs Van Haaften, Bert Van Der Zwaag, Mieke M. Van Haelst

Research output: Contribution to journalArticleProfessional

Abstract

Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades. Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part. In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity. The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesityassociated genes. An underlying obesityassociated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options. The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.

Translated title of the contributionGenetic obesity: New diagnostic options
LanguageDutch
Article numberD688
JournalNederlands Tijdschrift voor Geneeskunde
Volume161
Issue number19
Publication statusPublished - 2017

Cite this

De Vries, T. I., Alsters, S. I. M., Kleinendorst, L., Van Haaften, G., Van Der Zwaag, B., & Van Haelst, M. M. (2017). Genetische obesitas: NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN. Nederlands Tijdschrift voor Geneeskunde, 161(19), [D688].
De Vries, Tamar I. ; Alsters, Suzanne I.M. ; Kleinendorst, Lotte ; Van Haaften, Gijs ; Van Der Zwaag, Bert ; Van Haelst, Mieke M. / Genetische obesitas : NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN. In: Nederlands Tijdschrift voor Geneeskunde. 2017 ; Vol. 161, No. 19.
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abstract = "Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades. Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part. In approximately 5{\%} of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity. The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesityassociated genes. An underlying obesityassociated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options. The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.",
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De Vries, TI, Alsters, SIM, Kleinendorst, L, Van Haaften, G, Van Der Zwaag, B & Van Haelst, MM 2017, 'Genetische obesitas: NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN', Nederlands Tijdschrift voor Geneeskunde, vol. 161, no. 19, D688.

Genetische obesitas : NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN. / De Vries, Tamar I.; Alsters, Suzanne I.M.; Kleinendorst, Lotte; Van Haaften, Gijs; Van Der Zwaag, Bert; Van Haelst, Mieke M.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 161, No. 19, D688, 2017.

Research output: Contribution to journalArticleProfessional

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De Vries TI, Alsters SIM, Kleinendorst L, Van Haaften G, Van Der Zwaag B, Van Haelst MM. Genetische obesitas: NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN. Nederlands Tijdschrift voor Geneeskunde. 2017;161(19). D688.