Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Stephanie D. Hoekstra, Sven Stringer, Vivi M. Heine, Danielle Posthuma*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

Original languageEnglish
Article number164
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
Publication statusPublished - 13 Jun 2017

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