TY - JOUR
T1 - Genetische obesitas
T2 - NIEUWE DIAGNOSTISCHE MOGELIJKHEDEN
AU - De Vries, Tamar I.
AU - Alsters, Suzanne I.M.
AU - Kleinendorst, Lotte
AU - Van Haaften, Gijs
AU - Van Der Zwaag, Bert
AU - Van Haelst, Mieke M.
PY - 2017
Y1 - 2017
N2 - Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades. Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part. In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity. The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesityassociated genes. An underlying obesityassociated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options. The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.
AB - Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades. Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part. In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity. The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesityassociated genes. An underlying obesityassociated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options. The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.
UR - http://www.scopus.com/inward/record.url?scp=85019600937&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85019600937
SN - 0028-2162
VL - 161
JO - Nederlands Tijdschrift voor Geneeskunde
JF - Nederlands Tijdschrift voor Geneeskunde
IS - 19
M1 - D688
ER -