Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

Rita Guerreiro, Valentina Escott-Price, Lee Darwent, Laura Parkkinen, Olaf Ansorge, Dena G. Hernandez, Michael A. Nalls, Lorraine Clark, Lawrence Honig, Karen Marder, Wiesje van der Flier, Henne Holstege, Eva Louwersheimer, Afina Lemstra, Philip Scheltens, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Sara Ortega-CuberoPau Pastor, Tanis J. Ferman, Neill R. Graff-Radford, Owen A. Ross, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Walter Maetzler, Daniela Berg, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Yaroslau Compta, Tamas Revesz, Andrew Lees, Nigel J. Cairns, Glenda M. Halliday, David Mann, Stuart Pickering-Brown, John Powell, Katie Lunnon, Michelle K. Lupton, Dennis Dickson, John Hardy, Andrew Singleton, Jose Bras

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.
Original languageEnglish
Pages (from-to)214.e7e-214.e10
JournalNeurobiology of Aging
Volume38
DOIs
Publication statusPublished - Feb 2016

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